Bacopaside I alleviates depressive-like behaviors by modulating the gut microbiome and host metabolism in CUMS-induced mice

Bacopaside I (BSI) is a natural compound that is difficult to absorb orally but has been shown to have antidepressant effects. The microbiota-gut-brain axis is involved in the development of depression through the peripheral nervous system, endocrine system, and immune system and may be a key factor...

Full description

Saved in:
Bibliographic Details
Published inBiomedicine & pharmacotherapy Vol. 170; p. 115679
Main Authors Wang, Jie, Xin, Jiayun, Xu, Xike, Chen, Wei, Lv, Yanhui, Wei, Yanping, Wei, Xintong, Li, Zhanhong, Ding, Qianqian, Zhao, Houyu, Wen, Yukun, Zhang, Xiuyun, Fang, Yiqun, Zu, Xianpeng
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.01.2024
Elsevier
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Bacopaside I (BSI) is a natural compound that is difficult to absorb orally but has been shown to have antidepressant effects. The microbiota-gut-brain axis is involved in the development of depression through the peripheral nervous system, endocrine system, and immune system and may be a key factor in the effect of BSI. Therefore, this study aimed to investigate the potential mechanism of BSI in the treatment of depression via the microbiota-gut-brain axis and to validate it in a fecal microbiota transplantation model. The antidepressant effect of BSI was established in CUMS-induced mice using behavioral tests and measurement of changes in hypothalamicpituitaryadrenal (HPA) axis-related hormones. The improvement of stress-induced gut-brain axis damage by BSI was observed by histopathological sections and enzyme-linked immunosorbent assay (ELISA). 16 S rDNA sequencing analysis indicated that BSI could modulate the abundance of gut microbiota and increase the abundance of probiotic bacteria. We also observed an increase in short-chain fatty acids, particularly acetic acid. In addition, BSI could modulate the disruption of lipid metabolism induced by CUMS. Fecal microbiota transplantation further confirmed that disruption of the microbiota-gut-brain axis is closely associated with the development of depression, and that the microbiota regulated by BSI exerts a partial antidepressant effect. In conclusion, BSI exerts antidepressant effects by remodeling gut microbiota, specifically through the Lactobacillus and Streptococcus-acetic acid-neurotrophin signaling pathways. Furthermore, BSI can repair damage to the gut-brain axis, regulate HPA axis dysfunction, and maintain immune homeostasis. [Display omitted]
AbstractList Bacopaside I (BSI) is a natural compound that is difficult to absorb orally but has been shown to have antidepressant effects. The microbiota-gut-brain axis is involved in the development of depression through the peripheral nervous system, endocrine system, and immune system and may be a key factor in the effect of BSI. Therefore, this study aimed to investigate the potential mechanism of BSI in the treatment of depression via the microbiota-gut-brain axis and to validate it in a fecal microbiota transplantation model. The antidepressant effect of BSI was established in CUMS-induced mice using behavioral tests and measurement of changes in hypothalamicpituitaryadrenal (HPA) axis-related hormones. The improvement of stress-induced gut-brain axis damage by BSI was observed by histopathological sections and enzyme-linked immunosorbent assay (ELISA). 16 S rDNA sequencing analysis indicated that BSI could modulate the abundance of gut microbiota and increase the abundance of probiotic bacteria. We also observed an increase in short-chain fatty acids, particularly acetic acid. In addition, BSI could modulate the disruption of lipid metabolism induced by CUMS. Fecal microbiota transplantation further confirmed that disruption of the microbiota-gut-brain axis is closely associated with the development of depression, and that the microbiota regulated by BSI exerts a partial antidepressant effect. In conclusion, BSI exerts antidepressant effects by remodeling gut microbiota, specifically through the Lactobacillus and Streptococcus-acetic acid-neurotrophin signaling pathways. Furthermore, BSI can repair damage to the gut-brain axis, regulate HPA axis dysfunction, and maintain immune homeostasis.
Bacopaside I (BSI) is a natural compound that is difficult to absorb orally but has been shown to have antidepressant effects. The microbiota-gut-brain axis is involved in the development of depression through the peripheral nervous system, endocrine system, and immune system and may be a key factor in the effect of BSI. Therefore, this study aimed to investigate the potential mechanism of BSI in the treatment of depression via the microbiota-gut-brain axis and to validate it in a fecal microbiota transplantation model. The antidepressant effect of BSI was established in CUMS-induced mice using behavioral tests and measurement of changes in hypothalamicpituitaryadrenal (HPA) axis-related hormones. The improvement of stress-induced gut-brain axis damage by BSI was observed by histopathological sections and enzyme-linked immunosorbent assay (ELISA). 16 S rDNA sequencing analysis indicated that BSI could modulate the abundance of gut microbiota and increase the abundance of probiotic bacteria. We also observed an increase in short-chain fatty acids, particularly acetic acid. In addition, BSI could modulate the disruption of lipid metabolism induced by CUMS. Fecal microbiota transplantation further confirmed that disruption of the microbiota-gut-brain axis is closely associated with the development of depression, and that the microbiota regulated by BSI exerts a partial antidepressant effect. In conclusion, BSI exerts antidepressant effects by remodeling gut microbiota, specifically through the Lactobacillus and Streptococcus-acetic acid-neurotrophin signaling pathways. Furthermore, BSI can repair damage to the gut-brain axis, regulate HPA axis dysfunction, and maintain immune homeostasis.
Bacopaside I (BSI) is a natural compound that is difficult to absorb orally but has been shown to have antidepressant effects. The microbiota-gut-brain axis is involved in the development of depression through the peripheral nervous system, endocrine system, and immune system and may be a key factor in the effect of BSI. Therefore, this study aimed to investigate the potential mechanism of BSI in the treatment of depression via the microbiota-gut-brain axis and to validate it in a fecal microbiota transplantation model. The antidepressant effect of BSI was established in CUMS-induced mice using behavioral tests and measurement of changes in hypothalamicpituitaryadrenal (HPA) axis-related hormones. The improvement of stress-induced gut-brain axis damage by BSI was observed by histopathological sections and enzyme-linked immunosorbent assay (ELISA). 16 S rDNA sequencing analysis indicated that BSI could modulate the abundance of gut microbiota and increase the abundance of probiotic bacteria. We also observed an increase in short-chain fatty acids, particularly acetic acid. In addition, BSI could modulate the disruption of lipid metabolism induced by CUMS. Fecal microbiota transplantation further confirmed that disruption of the microbiota-gut-brain axis is closely associated with the development of depression, and that the microbiota regulated by BSI exerts a partial antidepressant effect. In conclusion, BSI exerts antidepressant effects by remodeling gut microbiota, specifically through the Lactobacillus and Streptococcus-acetic acid-neurotrophin signaling pathways. Furthermore, BSI can repair damage to the gut-brain axis, regulate HPA axis dysfunction, and maintain immune homeostasis. [Display omitted]
Bacopaside I (BSI) is a natural compound that is difficult to absorb orally but has been shown to have antidepressant effects. The microbiota-gut-brain axis is involved in the development of depression through the peripheral nervous system, endocrine system, and immune system and may be a key factor in the effect of BSI. Therefore, this study aimed to investigate the potential mechanism of BSI in the treatment of depression via the microbiota-gut-brain axis and to validate it in a fecal microbiota transplantation model. The antidepressant effect of BSI was established in CUMS-induced mice using behavioral tests and measurement of changes in hypothalamicpituitaryadrenal (HPA) axis-related hormones. The improvement of stress-induced gut-brain axis damage by BSI was observed by histopathological sections and enzyme-linked immunosorbent assay (ELISA). 16 S rDNA sequencing analysis indicated that BSI could modulate the abundance of gut microbiota and increase the abundance of probiotic bacteria. We also observed an increase in short-chain fatty acids, particularly acetic acid. In addition, BSI could modulate the disruption of lipid metabolism induced by CUMS. Fecal microbiota transplantation further confirmed that disruption of the microbiota-gut-brain axis is closely associated with the development of depression, and that the microbiota regulated by BSI exerts a partial antidepressant effect. In conclusion, BSI exerts antidepressant effects by remodeling gut microbiota, specifically through the Lactobacillus and Streptococcus-acetic acid-neurotrophin signaling pathways. Furthermore, BSI can repair damage to the gut-brain axis, regulate HPA axis dysfunction, and maintain immune homeostasis.
ArticleNumber 115679
Author Li, Zhanhong
Lv, Yanhui
Wang, Jie
Chen, Wei
Zhang, Xiuyun
Fang, Yiqun
Wen, Yukun
Wei, Xintong
Ding, Qianqian
Xin, Jiayun
Wei, Yanping
Xu, Xike
Zu, Xianpeng
Zhao, Houyu
Author_xml – sequence: 1
  givenname: Jie
  surname: Wang
  fullname: Wang, Jie
  organization: Department of Natural Medicinal Chemistry, School of Pharmacy, Naval Medical University, Shanghai 200433, China
– sequence: 2
  givenname: Jiayun
  surname: Xin
  fullname: Xin, Jiayun
  organization: Department of Natural Medicinal Chemistry, School of Pharmacy, Naval Medical University, Shanghai 200433, China
– sequence: 3
  givenname: Xike
  surname: Xu
  fullname: Xu, Xike
  organization: Department of Natural Medicinal Chemistry, School of Pharmacy, Naval Medical University, Shanghai 200433, China
– sequence: 4
  givenname: Wei
  surname: Chen
  fullname: Chen, Wei
  organization: Department of Natural Medicinal Chemistry, School of Pharmacy, Naval Medical University, Shanghai 200433, China
– sequence: 5
  givenname: Yanhui
  surname: Lv
  fullname: Lv, Yanhui
  organization: Department of Pharmaceutical Analysis, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
– sequence: 6
  givenname: Yanping
  surname: Wei
  fullname: Wei, Yanping
  organization: Department of Pharmaceutical Analysis, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
– sequence: 7
  givenname: Xintong
  surname: Wei
  fullname: Wei, Xintong
  organization: Department of Pharmaceutical Analysis, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
– sequence: 8
  givenname: Zhanhong
  surname: Li
  fullname: Li, Zhanhong
  organization: Department of Pharmaceutical Analysis, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510640, China
– sequence: 9
  givenname: Qianqian
  surname: Ding
  fullname: Ding, Qianqian
  organization: Department of Natural Medicinal Chemistry, School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230012, China
– sequence: 10
  givenname: Houyu
  surname: Zhao
  fullname: Zhao, Houyu
  organization: Department of Diving and Hyperbaric Medical Research, Naval Medical Center, Naval Medical University, Shanghai 200433, China
– sequence: 11
  givenname: Yukun
  surname: Wen
  fullname: Wen, Yukun
  organization: Department of Diving and Hyperbaric Medical Research, Naval Medical Center, Naval Medical University, Shanghai 200433, China
– sequence: 12
  givenname: Xiuyun
  orcidid: 0000-0003-2682-0755
  surname: Zhang
  fullname: Zhang, Xiuyun
  email: zhangxiuyunsh@163.com
  organization: Department of Pharmaceutical Analysis, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
– sequence: 13
  givenname: Yiqun
  surname: Fang
  fullname: Fang, Yiqun
  email: 1287225836@qq.com
  organization: Department of Diving and Hyperbaric Medical Research, Naval Medical Center, Naval Medical University, Shanghai 200433, China
– sequence: 14
  givenname: Xianpeng
  surname: Zu
  fullname: Zu, Xianpeng
  email: zuxianpeng@163.com
  organization: Department of Natural Medicinal Chemistry, School of Pharmacy, Naval Medical University, Shanghai 200433, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38113632$$D View this record in MEDLINE/PubMed
BookMark eNp9UcFu1DAUtFAR3Rb-ACEfuWTxi-0kviDBqrQrFXGAni3Hftn1ksSLnaxU8fN4SemR05Oe5s28mbkiF2MYkZC3wNbAoPpwWLc-HPdmXbKSrwFkVasXZAVKsqJirL4gK1ZLXnBelpfkKqUDY0xWvHlFLnkDwCtersjvz8aGo0neId1S0_d48mbCRB0eI6bkT1j0_ifSFvfm5ENMtH2kQ3BzbyY_7ui0R7qbJzp4G0P-aEBqRkf3IeUdTqYNvU8D9SPdPHz9XvjRzRbdGY6vycvO9AnfPM1r8vDl5sfmrrj_drvdfLovrKjFVJTZjGiBVQCWlw0o7iTWDVcgWtm47Em5TimulEQrHWtasJ2wTSmE6UAAvybbhdcFc9DH6AcTH3UwXv9dhLjTJk7e9qhrpRQDo6R1UmRBU1pWV7Wruto507DM9X7hOsbwa8Y06cEni31vRgxz0qViAqSA6iwrFmgOJqWI3bM0MH2uUB_0UqE-V6iXCvPZuyeFuR3QPR_96ywDPi4AzJmdPEadrMcxp-oj2imb8v9X-AMSvq9-
CitedBy_id crossref_primary_10_3390_antiox13040393
Cites_doi 10.1111/imm.12760
10.1021/np060470s
10.1016/j.canlet.2021.11.027
10.1038/s41401-018-0051-5
10.1073/pnas.0501526102
10.1080/15548627.2019.1607686
10.1080/10408398.2018.1529653
10.1039/D0FO00373E
10.1007/s00281-022-00948-2
10.1016/j.bbi.2020.03.015
10.3390/nu13114020
10.1016/j.phrs.2021.105840
10.3390/cells9051239
10.1038/s41598-020-77085-z
10.3390/nu13030927
10.1016/j.biopha.2022.112668
10.1038/s41598-021-04489-w
10.3389/fendo.2020.00025
10.1016/j.stemcr.2020.11.015
10.1186/s40168-017-0244-z
10.3109/21678421.2012.750364
10.1016/j.ijbiomac.2019.12.138
10.1038/mp.2016.120
10.1039/C8FO02096E
10.1016/j.jad.2022.05.044
10.3390/ijms23042013
10.15585/mmwr.mm7013e2
10.1016/j.cmet.2018.05.006
10.1016/j.ebiom.2017.09.013
10.1038/s41575-019-0157-3
10.1186/s12974-015-0281-0
10.1155/2016/9890141
10.1038/srep30046
10.4014/jmb.1805.05025
10.1038/nrdp.2016.65
10.1038/s41598-022-14837-z
10.1016/j.cpr.2020.101943
10.1073/pnas.0803702105
10.1016/j.jchromb.2016.05.031
10.1126/science.abi6087
10.1038/s41398-022-01836-x
10.1016/j.pnpbp.2021.110258
10.3389/fimmu.2017.01670
10.1038/mp.2016.44
10.1186/s12967-023-03993-z
10.3389/fpsyt.2022.815422
10.1007/s00018-020-03656-y
10.3389/fphar.2021.773562
10.2174/1570159X17666191001142934
10.3389/fpsyt.2020.00541
10.1016/j.jad.2016.05.038
10.1016/S0140-6736(65)90002-4
10.1016/j.bbi.2020.03.026
10.3390/molecules24030513
10.1136/gutjnl-2016-313332
10.1038/mp.2011.113
10.1186/s12974-022-02492-0
10.1016/j.jad.2020.11.121
10.1002/brb3.2453
10.1038/s41398-020-01024-9
10.1038/s41380-022-01456-3
10.1017/S1041610221000120
10.1038/s41398-022-02297-y
10.1007/s11064-017-2360-3
10.3168/jds.2018-14520
10.1016/j.pnpbp.2019.109794
10.1161/CIRCULATIONAHA.118.036652
10.1038/s41396-019-0571-0
10.1017/S0033291715002081
10.1038/s41398-021-01689-w
10.1080/19490976.2020.1854640
ContentType Journal Article
Copyright 2023 The Authors
Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Copyright_xml – notice: 2023 The Authors
– notice: Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
DBID 6I.
AAFTH
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOA
DOI 10.1016/j.biopha.2023.115679
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
Open Access: DOAJ - Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE


MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Pharmacy, Therapeutics, & Pharmacology
EISSN 1950-6007
EndPage 115679
ExternalDocumentID oai_doaj_org_article_799901a95cd54611a2c0767d6f7dda80
10_1016_j_biopha_2023_115679
38113632
S0753332223014774
Genre Journal Article
GroupedDBID ---
--K
--M
.1-
.FO
.GJ
.~1
0R~
0SF
1B1
1P~
1RT
1~.
1~5
23N
4.4
457
4CK
4G.
53G
5GY
5RE
5VS
6I.
7-5
71M
8P~
9JM
AABNK
AACTN
AAEDT
AAEDW
AAFTH
AAFWJ
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AAXUO
ABBQC
ABFNM
ABMAC
ABMZM
ABXDB
ABZDS
ACDAQ
ACIUM
ACRLP
ADBBV
ADEZE
ADMUD
ADVLN
AEBSH
AEKER
AENEX
AEVXI
AFCTW
AFKWA
AFPKN
AFRHN
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AHHHB
AI.
AIEXJ
AIKHN
AITUG
AJOXV
AJRQY
AJUYK
AKRWK
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
CS3
DU5
EBS
EFJIC
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
GROUPED_DOAJ
HMT
HVGLF
HZ~
IHE
J1W
KOM
M34
M41
MO0
N9A
NCXOZ
O-L
O9-
OAUVE
OD~
OGGZJ
OK1
OO0
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SDF
SDG
SDP
SEM
SES
SEW
SPT
SSH
SSP
SSZ
T5K
VH1
WUQ
Z5R
~02
~G-
AAXKI
AFJKZ
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c474t-20074b10611c328193d5e783914b58d0569df993995ec5d08b1cf4c8244af1413
IEDL.DBID DOA
ISSN 0753-3322
IngestDate Tue Oct 22 15:11:26 EDT 2024
Fri Oct 25 06:37:14 EDT 2024
Thu Sep 26 20:38:08 EDT 2024
Thu Oct 24 09:49:46 EDT 2024
Sat Aug 10 15:30:50 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Short-chain fatty acids
DSR
Microbiota-gut-brain axis
DG
PAS
Fecal microbiota transplantation
CUMS
Bacopaside I
ACTH
Depression
Lipidomics
IL-1β
IL-6
LPS
COVID-19
CORT
NF-κB
ZO-1
AB-PAS
TNF-α
ELSA
CRH
HPA
SCFAs
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-20074b10611c328193d5e783914b58d0569df993995ec5d08b1cf4c8244af1413
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-2682-0755
OpenAccessLink https://doaj.org/article/799901a95cd54611a2c0767d6f7dda80
PMID 38113632
PQID 2904154161
PQPubID 23479
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_799901a95cd54611a2c0767d6f7dda80
proquest_miscellaneous_2904154161
crossref_primary_10_1016_j_biopha_2023_115679
pubmed_primary_38113632
elsevier_sciencedirect_doi_10_1016_j_biopha_2023_115679
PublicationCentury 2000
PublicationDate January 2024
2024-Jan
2024-01-00
20240101
2024-01-01
PublicationDateYYYYMMDD 2024-01-01
PublicationDate_xml – month: 01
  year: 2024
  text: January 2024
PublicationDecade 2020
PublicationPlace France
PublicationPlace_xml – name: France
PublicationTitle Biomedicine & pharmacotherapy
PublicationTitleAlternate Biomed Pharmacother
PublicationYear 2024
Publisher Elsevier Masson SAS
Elsevier
Publisher_xml – name: Elsevier Masson SAS
– name: Elsevier
References Yin, Xiong, Wen, Song, Xu (bib16) 2016; 1027
Wang, Dong, Hu, Qu, Lu, Zhou, Li, Pei (bib27) 2021; 16
Otte, Gold, Penninx, Pariante, Etkin, Fava, Mohr, Schatzberg (bib1) 2016; 2
Cox, Banack, Murch, Rasmussen, Tien, Bidigare, Metcalf, Morrison, Codd, Bergman (bib36) 2005; 102
Cignarella, Cantoni, Ghezzi, Salter, Dorsett, Chen, Phillips, Weinstock, Fontana, Cross, Zhou, Piccio (bib19) 2018; 27
Bryan, Karla, Edgar Alejandro, Sara Elva, Gemma, Luz (bib63) 2016; 2016
Dalile, Van Oudenhove, Vervliet, Verbeke (bib51) 2019; 16
Hussain, Anwar, Rasul, Imran, Qasim, Zafar, Imran, Kamran, Aziz, Razzaq, Ahmad, Shabbir, Iqbal, Baig, Ali, Gonzalez de Aguilar, Sun, Muhammad, Muhammad (bib58) 2020; 60
Bradley, Borenstein, Nelson, Codd, Rosen, Stommel, Cox (bib37) 2013; 14
Simpson, Diaz-Arteche, Eliby, Schwartz, Simmons, Cowan (bib48) 2021; 83
Yan, Jiao, Chen, Zhang, Wang, Jiang, Liu, Xue, Ma, Li, Chen (bib61) 2021; 12
Liu, Yue, Zhang, Shan, Wang, Zhang (bib13) 2013; 31
Wasilewska, Zlotkowska, Wroblewska (bib69) 2019; 102
Athira, Bandopadhyay, Samudrala, Naidu, Lahkar, Chakravarty (bib5) 2020; 18
Kim, Jeon, Kim, Seol, Jo, Cho, Kim (bib42) 2022; 12
Wang, He, Sun, Ren, Liu, Wang, Yang (bib24) 2022; 19
Tamargo, Molinero, Reinosa, Alcolea-Rodriguez, Portela, Banares, Fernandez, Moreno-Arribas (bib35) 2022; 12
Keller, Gomez, Williams, Lembke, Lazzeroni, Murphy, Schatzberg (bib21) 2017; 22
Vahratian, Blumberg, Terlizzi, Schiller (bib3) 2021; 70
Guo, Zhang, Hao, Wang, Zhang, Liu (bib23) 2023; 13
Green, Davis, Berk, Hair, Loughman, Castle, Athan, Nierenberg, Cryan, Jacka, Marx (bib70) 2020; 12
Tang, Wei, Li, Chen, Chen, Wang, Yang, Miao, Xiao, Zhang, Lian, Jiang, Zhang, Cao, Fan, Wu, Qiu, Fang, Ansari, Gershwin, Ma (bib20) 2018; 67
Herselman, Bailey, Bobrovskaya (bib29) 2022; 23
Agirman, Yu, Hsiao (bib31) 2021; 374
Aizawa, Tsuji, Asahara, Takahashi, Teraishi, Yoshida, Ota, Koga, Hattori, Kunugi (bib39) 2016; 202
Zu, Zhang, Li, Xie, Lin, Yang, Liu, Zhang (bib15) 2017; 42
Hou, Chen, Zhang, Zhang, Liu, Wang, Dai, Wang, Zhong, Cao (bib50) 2022; 526
Huang, Hu, Cai, Zeng, Fang, Dai, Ye, Chen, Zhang (bib52) 2021; 281
Settanni, Ianiro, Bibbo, Cammarota, Gasbarrini (bib72) 2021; 109
Borrelli, Aceto, Agnisola, De Paolo, Dipineto, Stilling, Dinan, Cryan, Menna, Fioretti (bib44) 2016; 6
McGuinness, Davis, Dawson, Loughman, Collier, O'Hely, Simpson, Green, Marx, Hair, Guest, Mohebbi, Berk, Stupart, Watters, Jacka (bib45) 2022; 27
Chen, Zhang, Ren, Role (bib43) 2019; 24
Socala, Doboszewska, Szopa, Serefko, Wlodarczyk, Zielinska, Poleszak, Fichna, Wlaz (bib26) 2021; 172
Slykerman, Hood, Wickens, Thompson, Barthow, Murphy, Kang, Rowden, Stone, Crane, Stanley, Abels, Purdie, Maude, Mitchell (bib41) 2017; 24
Hao, Michaelsen, Singleton, Dottorini, Kirkegaard, Albertsen, Nielsen, Dueholm (bib34) 2020; 14
Zhang, Li, Yang, Li, Zheng, Wang, Sun, Huang, Zhang, Song, Liu (bib18) 2023; 21
Meeking, MacFabe, Mepham, Foley, Tichenoff, Boon, Kavaliers, Ossenkopp (bib54) 2020; 97
Frye, Nankova, Bhattacharyya, Rose, Bennuri, MacFabe (bib57) 2017; 8
Larsen (bib49) 2017; 151
bib4
Bekhbat, Treadway, Goldsmith, Woolwine, Haroon, Miller, Felger (bib66) 2020; 88
Liu, Wang, Gui, Zeng, Pu, Zheng, Zeng, Luo, Wu, Zhou, Song, Ji, Wei, Xie (bib73) 2021; 11
Bartolomaeus, Balogh, Yakoub, Homann, Markó, Höges, Tsvetkov, Krannich, Wundersitz, Avery, Haase, Kräker, Hering, Maase, Kusche-Vihrog, Grandoch, Fielitz, Kempa, Gollasch, Zhumadilov, Kozhakhmetov, Kushugulova, Eckardt, Dechend, Rump, Forslund, Müller, Stegbauer, Wilck (bib55) 2019; 139
Demirkan, Lahti, Direk, Viktorin, Lunetta, Terracciano, Nalls, Tanaka, Hek, Fornage, Wellmann, Cornelis, Ollila, Yu, Smith, Pilling, Isaacs, Palotie, Zhuang, Zonderman, Faul, Sutin, Meirelles, Mulas, Hofman, Uitterlinden, Rivadeneira, Perola, Zhao, Salomaa, Yaffe, Luik, Nabec, Liu, Ding, Lichtenstein, Landen, Widen, Weir, Llewellyn, Murray, Kardia, Eriksson, Koenen, Magnusson, Ferrucci, Mosley, Cucca, Oostra, Bennett, Paunio, Berger, Harris, Pedersen, Murabito, Tiemeier, van Duijn, Raikkonen (bib2) 2016; 46
Wang, Liu, Rao, Zeng, Yu, Zhou, Zeng, Zheng, Pu, Xu, Cheng, Zhang, Ji, Wei, Xie (bib74) 2020; 10
Yan, Nian, Liao, Xiao, Wu, Bi, He, Jia (bib75) 2020; 144
Yin, Wang, Zhang (bib65) 2019; 40
Zoicas, Muhle, Schmidtner, Gulbins, Neumann, Kornhuber (bib64) 2020; 9
Song, Wang, Ding, Wang, Ye, Chen, Ma (bib47) 2022; 310
Johnston, Jasbi, Jin, Bauer, Williams, Fessler, Gu (bib53) 2021; 13
Macbeth, Kass, McDermott (bib7) 1965; 1
Xie, Yuan, Tan, Bai, Zheng, Mao, Wu, Wang, Da, Ye, Zhang, Wang, Yin, Bian, Ma, Zhang, Zhang, Yu, Guo (bib38) 2022; 12
Guilloux, Douillard-Guilloux, Kota, Wang, Gardier, Martinowich, Tseng, Lewis, Sibille (bib60) 2012; 17
Barandouzi, Starkweather, Henderson, Gyamfi, Cong (bib9) 2020; 11
Lee, Dong, Krause-Sorio, Siddarth, Milillo, Lagishetty, Datta, Aguilar-Faustino, Jacobs, Lavretsky (bib46) 2022; 34
Sookying, Pekthong, Oo-Puthinan, Nuengchamnong, Ingkaninan (bib17) 2017; 12
Nguyen, Palm (bib6) 2022; 44
Hao, Gao, Liu, Rong, Jia, Kang, Guo, Li (bib56) 2020; 10
Bergami, Rimondini, Santi, Blum, Götz, Canossa (bib59) 2008; 105
Zonis, Pechnick, Ljubimov, Mahgerefteh, Wawrowsky, Michelsen, Chesnokova (bib22) 2015; 12
Wu, Chai, Zhang, Huang, Perry, Li, Duan, Tan, Hu, Liu, Pu, Wang, Song, Jin, Ji, Zheng, Xie (bib11) 2022; 12
Gu, Wu, Liu, Dou, Jiang, Liang (bib67) 2020; 11
Ciesielska, Matyjek, Kwiatkowska (bib30) 2021; 78
Trzeciak, Herbet (bib25) 2021; 13
Lou, Cao, Jin, Mi, Xiong, Zeng, Pan, Qie, Qiu, Niu, Liang, Liu, Chen, Liu, Zhao, Qiu, Jin, Sheng, Hu, Jin, Liu, Liu, Wang (bib8) 2022; 71
Lee, Lim, Kim (bib68) 2018; 28
Tayab, Islam, Chowdhury, Tasnim (bib62) 2022; 147
Sun, Geng, Pan, Wang, Xiao, Wang (bib40) 2019; 10
Doll, Vazquez-Castellanos, Schaub, Schweinfurth, Kettelhack, Schneider, Yamanbaeva, Mahlmann, Brand, Beglinger, Borgwardt, Raes, Schmidt, Lang (bib71) 2022; 13
Liu, Rowan-Nash, Sheehan, Walsh, Sanzari, Korry, Belenky (bib32) 2020; 88
Thangaraj, Periyasamy, Guo, Chivero, Callen, Buch (bib28) 2020; 16
Silva, Bernardi, Frozza (bib12) 2020; 11
Zhou, Shen, Zhang, Su, Liu, Zhang (bib14) 2007; 70
Zheng, Zeng, Zhou, Liu, Fang, Xu, Zeng, Chen, Fan, Du, Zhang, Yang, Yang, Meng, Li, Melgiri, Licinio, Wei, Xie (bib10) 2016; 21
Bradley, Pollard (bib33) 2017; 5
Lou (10.1016/j.biopha.2023.115679_bib8) 2022; 71
Bryan (10.1016/j.biopha.2023.115679_bib63) 2016; 2016
Aizawa (10.1016/j.biopha.2023.115679_bib39) 2016; 202
Barandouzi (10.1016/j.biopha.2023.115679_bib9) 2020; 11
Socala (10.1016/j.biopha.2023.115679_bib26) 2021; 172
Huang (10.1016/j.biopha.2023.115679_bib52) 2021; 281
Guo (10.1016/j.biopha.2023.115679_bib23) 2023; 13
Doll (10.1016/j.biopha.2023.115679_bib71) 2022; 13
Bekhbat (10.1016/j.biopha.2023.115679_bib66) 2020; 88
Macbeth (10.1016/j.biopha.2023.115679_bib7) 1965; 1
Lee (10.1016/j.biopha.2023.115679_bib46) 2022; 34
Zoicas (10.1016/j.biopha.2023.115679_bib64) 2020; 9
Liu (10.1016/j.biopha.2023.115679_bib73) 2021; 11
Simpson (10.1016/j.biopha.2023.115679_bib48) 2021; 83
Dalile (10.1016/j.biopha.2023.115679_bib51) 2019; 16
Green (10.1016/j.biopha.2023.115679_bib70) 2020; 12
Hao (10.1016/j.biopha.2023.115679_bib34) 2020; 14
Sun (10.1016/j.biopha.2023.115679_bib40) 2019; 10
Herselman (10.1016/j.biopha.2023.115679_bib29) 2022; 23
Meeking (10.1016/j.biopha.2023.115679_bib54) 2020; 97
Otte (10.1016/j.biopha.2023.115679_bib1) 2016; 2
Nguyen (10.1016/j.biopha.2023.115679_bib6) 2022; 44
Zheng (10.1016/j.biopha.2023.115679_bib10) 2016; 21
Ciesielska (10.1016/j.biopha.2023.115679_bib30) 2021; 78
Yin (10.1016/j.biopha.2023.115679_bib16) 2016; 1027
Slykerman (10.1016/j.biopha.2023.115679_bib41) 2017; 24
Wasilewska (10.1016/j.biopha.2023.115679_bib69) 2019; 102
Settanni (10.1016/j.biopha.2023.115679_bib72) 2021; 109
Cignarella (10.1016/j.biopha.2023.115679_bib19) 2018; 27
Vahratian (10.1016/j.biopha.2023.115679_bib3) 2021; 70
Demirkan (10.1016/j.biopha.2023.115679_bib2) 2016; 46
Liu (10.1016/j.biopha.2023.115679_bib13) 2013; 31
Zonis (10.1016/j.biopha.2023.115679_bib22) 2015; 12
Yan (10.1016/j.biopha.2023.115679_bib75) 2020; 144
Hou (10.1016/j.biopha.2023.115679_bib50) 2022; 526
Bradley (10.1016/j.biopha.2023.115679_bib37) 2013; 14
Sookying (10.1016/j.biopha.2023.115679_bib17) 2017; 12
Bradley (10.1016/j.biopha.2023.115679_bib33) 2017; 5
Johnston (10.1016/j.biopha.2023.115679_bib53) 2021; 13
Tang (10.1016/j.biopha.2023.115679_bib20) 2018; 67
Keller (10.1016/j.biopha.2023.115679_bib21) 2017; 22
Xie (10.1016/j.biopha.2023.115679_bib38) 2022; 12
Yin (10.1016/j.biopha.2023.115679_bib65) 2019; 40
Athira (10.1016/j.biopha.2023.115679_bib5) 2020; 18
Bergami (10.1016/j.biopha.2023.115679_bib59) 2008; 105
Gu (10.1016/j.biopha.2023.115679_bib67) 2020; 11
Zhang (10.1016/j.biopha.2023.115679_bib18) 2023; 21
Lee (10.1016/j.biopha.2023.115679_bib68) 2018; 28
Wang (10.1016/j.biopha.2023.115679_bib24) 2022; 19
Tamargo (10.1016/j.biopha.2023.115679_bib35) 2022; 12
Silva (10.1016/j.biopha.2023.115679_bib12) 2020; 11
Thangaraj (10.1016/j.biopha.2023.115679_bib28) 2020; 16
Borrelli (10.1016/j.biopha.2023.115679_bib44) 2016; 6
Zu (10.1016/j.biopha.2023.115679_bib15) 2017; 42
Trzeciak (10.1016/j.biopha.2023.115679_bib25) 2021; 13
Wang (10.1016/j.biopha.2023.115679_bib74) 2020; 10
Chen (10.1016/j.biopha.2023.115679_bib43) 2019; 24
Tayab (10.1016/j.biopha.2023.115679_bib62) 2022; 147
Cox (10.1016/j.biopha.2023.115679_bib36) 2005; 102
Frye (10.1016/j.biopha.2023.115679_bib57) 2017; 8
Yan (10.1016/j.biopha.2023.115679_bib61) 2021; 12
Agirman (10.1016/j.biopha.2023.115679_bib31) 2021; 374
Hao (10.1016/j.biopha.2023.115679_bib56) 2020; 10
Guilloux (10.1016/j.biopha.2023.115679_bib60) 2012; 17
Liu (10.1016/j.biopha.2023.115679_bib32) 2020; 88
Wu (10.1016/j.biopha.2023.115679_bib11) 2022; 12
Hussain (10.1016/j.biopha.2023.115679_bib58) 2020; 60
Wang (10.1016/j.biopha.2023.115679_bib27) 2021; 16
Bartolomaeus (10.1016/j.biopha.2023.115679_bib55) 2019; 139
McGuinness (10.1016/j.biopha.2023.115679_bib45) 2022; 27
Song (10.1016/j.biopha.2023.115679_bib47) 2022; 310
Kim (10.1016/j.biopha.2023.115679_bib42) 2022; 12
Larsen (10.1016/j.biopha.2023.115679_bib49) 2017; 151
Zhou (10.1016/j.biopha.2023.115679_bib14) 2007; 70
References_xml – volume: 28
  start-page: 1443
  year: 2018
  end-page: 1446
  ident: bib68
  article-title: Lactobacillus johnsonii CJLJ103 Attenuates Scopolamine-Induced Memory Impairment in Mice by Increasing BDNF Expression and Inhibiting NF-kappaB
  publication-title: Act., J. Microbiol. Biotechnol.
  contributor:
    fullname: Kim
– volume: 1027
  start-page: 103
  year: 2016
  end-page: 109
  ident: bib16
  article-title: A simple LC-ESI-MS/MS method for quantification of bacopaside I in rat plasma and its application to a pharmacokinetic study
  publication-title: J. Chromatogr. B
  contributor:
    fullname: Xu
– volume: 526
  start-page: 225
  year: 2022
  end-page: 235
  ident: bib50
  article-title: Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?
  publication-title: Cancer Lett.
  contributor:
    fullname: Cao
– volume: 2016
  start-page: 9890141
  year: 2016
  ident: bib63
  article-title: Sphingolipids as mediators in the crosstalk between microbiota and intestinal cells: implications for inflammatory bowel disease
  publication-title: Mediat. Inflamm.
  contributor:
    fullname: Luz
– volume: 21
  start-page: 145
  year: 2023
  ident: bib18
  article-title: Matrine alleviates depressive-like behaviors via modulating microbiota-gut-brain axis in CUMS-induced mice
  publication-title: J. Transl. Med
  contributor:
    fullname: Liu
– volume: 11
  start-page: 6148
  year: 2020
  end-page: 6157
  ident: bib67
  article-title: Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota
  publication-title: Food Funct.
  contributor:
    fullname: Liang
– volume: 24
  start-page: 513
  year: 2019
  ident: bib43
  article-title: of Exopolysaccharide Produced by Streptococcus thermophilus in the Intestinal Inflammation and Mucosal Barrier in Caco-2 Monolayer and Dextran Sulphate Sodium-Induced Experimental Murine Colitis
  publication-title: Molecules
  contributor:
    fullname: Role
– volume: 12
  year: 2021
  ident: bib61
  article-title: Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis
  publication-title: Front. Pharmacol.
  contributor:
    fullname: Chen
– volume: 16
  start-page: 75
  year: 2021
  end-page: 88
  ident: bib27
  article-title: Constitutive activity of serotonin receptor 6 regulates human cerebral organoids formation and depression-like behaviors
  publication-title: Stem Cell Rep.
  contributor:
    fullname: Pei
– volume: 9
  start-page: 1239
  year: 2020
  ident: bib64
  article-title: Anxiety and depression are related to higher activity of sphingolipid metabolizing enzymes in the rat brain
  publication-title: Cells
  contributor:
    fullname: Kornhuber
– volume: 11
  start-page: 25
  year: 2020
  ident: bib12
  article-title: The role of short-chain fatty acids from gut microbiota in gut-brain communication
  publication-title: Front. Endocrinol.
  contributor:
    fullname: Frozza
– volume: 139
  start-page: 1407
  year: 2019
  end-page: 1421
  ident: bib55
  article-title: Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage
  publication-title: Circulation
  contributor:
    fullname: Wilck
– volume: 12
  start-page: 528
  year: 2022
  ident: bib35
  article-title: PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion
  publication-title: Sci. Rep.
  contributor:
    fullname: Moreno-Arribas
– volume: 88
  start-page: 161
  year: 2020
  end-page: 165
  ident: bib66
  article-title: Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia
  publication-title: Brain, Behav., Immun.
  contributor:
    fullname: Felger
– volume: 27
  start-page: 1222
  year: 2018
  end-page: 1235
  ident: bib19
  article-title: Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota
  publication-title: Cell Metab.
  contributor:
    fullname: Piccio
– volume: 374
  start-page: 1087
  year: 2021
  end-page: 1092
  ident: bib31
  article-title: Signaling inflammation across the gut-brain axis
  publication-title: Science
  contributor:
    fullname: Hsiao
– volume: 12
  start-page: 13274
  year: 2022
  ident: bib42
  article-title: Investigation of memory-enhancing effects of Streptococcus thermophilus EG007 in mice and elucidating molecular and metagenomic characteristics using nanopore sequencing
  publication-title: Sci. Rep.
  contributor:
    fullname: Kim
– volume: 97
  year: 2020
  ident: bib54
  article-title: Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  contributor:
    fullname: Ossenkopp
– volume: 22
  start-page: 527
  year: 2017
  end-page: 536
  ident: bib21
  article-title: HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition
  publication-title: Mol. Psychiatry
  contributor:
    fullname: Schatzberg
– volume: 70
  start-page: 490
  year: 2021
  end-page: 494
  ident: bib3
  article-title: Symptoms of anxiety or depressive disorder and use of mental health care among adults during the COVID-19 Pandemic - United States, August 2020-February 2021
  publication-title: Morb. Mortal. Wkly. Rep.
  contributor:
    fullname: Schiller
– volume: 172
  year: 2021
  ident: bib26
  article-title: The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders
  publication-title: Pharmacol. Res.
  contributor:
    fullname: Wlaz
– volume: 5
  start-page: 36
  year: 2017
  ident: bib33
  article-title: Proteobacteria explain significant functional variability in the human gut microbiome
  publication-title: Microbiome
  contributor:
    fullname: Pollard
– volume: 10
  start-page: 346
  year: 2020
  ident: bib74
  article-title: Integrated phosphoproteomic and metabolomic profiling reveals perturbed pathways in the hippocampus of gut microbiota dysbiosis mice
  publication-title: Transl. Psychiatry
  contributor:
    fullname: Xie
– volume: 10
  start-page: 19917
  year: 2020
  ident: bib56
  article-title: Intravenous administration of sodium propionate induces antidepressant or prodepressant effect in a dose dependent manner
  publication-title: Sci. Rep.
  contributor:
    fullname: Li
– volume: 60
  start-page: 351
  year: 2020
  end-page: 374
  ident: bib58
  article-title: Umair, Lipids as biomarkers of brain disorders
  publication-title: Crit. Rev. Food Sci. Nutr.
  contributor:
    fullname: Muhammad
– volume: 40
  start-page: 336
  year: 2019
  end-page: 341
  ident: bib65
  article-title: Integrating endocannabinoid signaling in the regulation of anxiety and depression
  publication-title: Acta Pharmacol. Sin.
  contributor:
    fullname: Zhang
– volume: 13
  start-page: 4020
  year: 2021
  ident: bib53
  article-title: Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial
  publication-title: Nutrients
  contributor:
    fullname: Gu
– volume: 105
  start-page: 15570
  year: 2008
  end-page: 15575
  ident: bib59
  article-title: Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Canossa
– volume: 12
  year: 2022
  ident: bib38
  article-title: The combination of living Bifidobacterium, Lactobacillus, and Streptococcus improves social ranking and relieves anxiety-like behaviors in competitive mice in a social dominance tube test
  publication-title: Brain Behav.
  contributor:
    fullname: Guo
– volume: 21
  start-page: 786
  year: 2016
  end-page: 796
  ident: bib10
  article-title: Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism
  publication-title: Mol. Psychiatry
  contributor:
    fullname: Xie
– volume: 46
  start-page: 1613
  year: 2016
  end-page: 1623
  ident: bib2
  article-title: Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies
  publication-title: Psychol. Med
  contributor:
    fullname: Raikkonen
– volume: 16
  start-page: 461
  year: 2019
  end-page: 478
  ident: bib51
  article-title: The role of short-chain fatty acids in microbiota-gut-brain communication
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  contributor:
    fullname: Verbeke
– volume: 13
  start-page: 5
  year: 2023
  ident: bib23
  article-title: Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression
  publication-title: Transl. Psychiatry
  contributor:
    fullname: Liu
– volume: 44
  start-page: 569
  year: 2022
  end-page: 579
  ident: bib6
  article-title: Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries
  publication-title: Semin. Immunopathol.
  contributor:
    fullname: Palm
– volume: 83
  year: 2021
  ident: bib48
  article-title: The gut microbiota in anxiety and depression - A systematic review
  publication-title: Clin. Psychol. Rev.
  contributor:
    fullname: Cowan
– volume: 281
  start-page: 51
  year: 2021
  end-page: 60
  ident: bib52
  article-title: Acetate supplementation produces antidepressant-like effect via enhanced histone acetylation
  publication-title: J. Affect. Disord.
  contributor:
    fullname: Zhang
– volume: 12
  start-page: 74
  year: 2022
  ident: bib11
  article-title: Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model
  publication-title: Transl. Psychiatry
  contributor:
    fullname: Xie
– volume: 88
  start-page: 308
  year: 2020
  end-page: 324
  ident: bib32
  article-title: Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults
  publication-title: Brain, Behav., Immun.
  contributor:
    fullname: Belenky
– volume: 71
  start-page: 1588
  year: 2022
  end-page: 1599
  ident: bib8
  article-title: Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder
  publication-title: Gut
  contributor:
    fullname: Wang
– volume: 27
  start-page: 1920
  year: 2022
  end-page: 1935
  ident: bib45
  article-title: A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia
  publication-title: Mol. Psychiatry
  contributor:
    fullname: Jacka
– volume: 11
  start-page: 541
  year: 2020
  ident: bib9
  article-title: Altered Composition of Gut Microbiota in Depression: A Systematic Review
  publication-title: Front. Psychiatry
  contributor:
    fullname: Cong
– volume: 144
  start-page: 427
  year: 2020
  end-page: 440
  ident: bib75
  article-title: Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota
  publication-title: Int. J. Biol. Macromol.
  contributor:
    fullname: Jia
– ident: bib4
– volume: 78
  start-page: 1233
  year: 2021
  end-page: 1261
  ident: bib30
  article-title: TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
  publication-title: Cell. Mol. Life Sci.
  contributor:
    fullname: Kwiatkowska
– volume: 34
  start-page: 33
  year: 2022
  end-page: 45
  ident: bib46
  article-title: The intestinal microbiota as a predictor for antidepressant treatment outcome in geriatric depression: a prospective pilot study
  publication-title: Int. Psychogeriatr.
  contributor:
    fullname: Lavretsky
– volume: 14
  start-page: 906
  year: 2020
  end-page: 918
  ident: bib34
  article-title: Novel syntrophic bacteria in full-scale anaerobic digesters revealed by genome-centric metatranscriptomics
  publication-title: ISME J.
  contributor:
    fullname: Dueholm
– volume: 2
  start-page: 16065
  year: 2016
  ident: bib1
  article-title: Major depressive disorder
  publication-title: Nat. Rev. Dis. Prim.
  contributor:
    fullname: Schatzberg
– volume: 19
  start-page: 132
  year: 2022
  ident: bib24
  article-title: Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression
  publication-title: J. Neuroinflamm.
  contributor:
    fullname: Yang
– volume: 13
  year: 2022
  ident: bib71
  article-title: Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression-Case Report
  publication-title: Front. Psychiatry
  contributor:
    fullname: Lang
– volume: 147
  year: 2022
  ident: bib62
  article-title: Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression
  publication-title: Biomed. Pharmacother.
  contributor:
    fullname: Tasnim
– volume: 67
  start-page: 534
  year: 2018
  end-page: 541
  ident: bib20
  article-title: Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy
  publication-title: Gut
  contributor:
    fullname: Ma
– volume: 11
  start-page: 568
  year: 2021
  ident: bib73
  article-title: Proteomics analysis of the gut-brain axis in a gut microbiota-dysbiosis model of depression
  publication-title: Transl. Psychiatry
  contributor:
    fullname: Xie
– volume: 6
  start-page: 30046
  year: 2016
  ident: bib44
  article-title: Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish
  publication-title: Sci. Rep.
  contributor:
    fullname: Fioretti
– volume: 202
  start-page: 254
  year: 2016
  end-page: 257
  ident: bib39
  article-title: Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder
  publication-title: J. Affect. Disord.
  contributor:
    fullname: Kunugi
– volume: 12
  start-page: 1
  year: 2020
  end-page: 25
  ident: bib70
  article-title: Efficacy and safety of fecal microbiota transplantation for the treatment of diseases other than Clostridium difficile infection: a systematic review and meta-analysis
  publication-title: Gut Microbes
  contributor:
    fullname: Marx
– volume: 12
  year: 2017
  ident: bib17
  article-title: Quantitation of Bacopaside I in Rat Biological Samples by LC-QTOF-MS/MS and Its Pharmacokinetic Application
  publication-title: Nat. Prod. Commun.
  contributor:
    fullname: Ingkaninan
– volume: 70
  start-page: 652
  year: 2007
  end-page: 655
  ident: bib14
  article-title: Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models
  publication-title: J. Nat. Prod.
  contributor:
    fullname: Zhang
– volume: 42
  start-page: 3233
  year: 2017
  end-page: 3244
  ident: bib15
  article-title: Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway
  publication-title: Neurochem. Res.
  contributor:
    fullname: Zhang
– volume: 17
  start-page: 1130
  year: 2012
  end-page: 1142
  ident: bib60
  article-title: Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression
  publication-title: Mol. Psychiatry
  contributor:
    fullname: Sibille
– volume: 102
  start-page: 37
  year: 2019
  end-page: 53
  ident: bib69
  article-title: Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis
  publication-title: J. Dairy Sci.
  contributor:
    fullname: Wroblewska
– volume: 8
  start-page: 1670
  year: 2017
  ident: bib57
  article-title: Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid
  publication-title: Front. Immunol.
  contributor:
    fullname: MacFabe
– volume: 151
  start-page: 363
  year: 2017
  end-page: 374
  ident: bib49
  article-title: The immune response to Prevotella bacteria in chronic inflammatory disease
  publication-title: Immunology
  contributor:
    fullname: Larsen
– volume: 24
  start-page: 159
  year: 2017
  end-page: 165
  ident: bib41
  article-title: G. Probiotic in Pregnancy Study, Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial
  publication-title: EBioMedicine
  contributor:
    fullname: Mitchell
– volume: 14
  start-page: 325
  year: 2013
  end-page: 333
  ident: bib37
  article-title: Is exposure to cyanobacteria an environmental risk factor for amyotrophic lateral sclerosis and other neurodegenerative diseases?
  publication-title: Amyotroph. Lateral Scler. Front. Degener.
  contributor:
    fullname: Cox
– volume: 31
  start-page: 109
  year: 2013
  end-page: 123
  ident: bib13
  article-title: Neuroprotective effects of bacopaside I in ischemic brain injury
  publication-title: Restor. Neurol. Neurosci.
  contributor:
    fullname: Zhang
– volume: 23
  start-page: 2013
  year: 2022
  ident: bib29
  article-title: The Effects of Stress and Diet on the "Brain-Gut" and "Gut-Brain" Pathways in Animal Models of Stress and Depression
  publication-title: Int. J. Mol. Sci.
  contributor:
    fullname: Bobrovskaya
– volume: 12
  start-page: 65
  year: 2015
  ident: bib22
  article-title: Chronic intestinal inflammation alters hippocampal neurogenesis
  publication-title: J. Neuroinflamm.
  contributor:
    fullname: Chesnokova
– volume: 1
  start-page: 399
  year: 1965
  end-page: 403
  ident: bib7
  article-title: Treatment of hepatic encephalopathy by alteration of intestinal flora with lactobacillus acidophilus
  publication-title: Lancet
  contributor:
    fullname: McDermott
– volume: 16
  start-page: 289
  year: 2020
  end-page: 312
  ident: bib28
  article-title: Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics
  publication-title: Autophagy
  contributor:
    fullname: Buch
– volume: 102
  start-page: 5074
  year: 2005
  end-page: 5078
  ident: bib36
  article-title: Diverse taxa of cyanobacteria produce beta-N-methylamino-
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Bergman
– volume: 18
  start-page: 168
  year: 2020
  end-page: 187
  ident: bib5
  article-title: An overview of the heterogeneity of major depressive disorder: current knowledge and future prospective
  publication-title: Curr. Neuropharmacol.
  contributor:
    fullname: Chakravarty
– volume: 109
  year: 2021
  ident: bib72
  article-title: Gut microbiota alteration and modulation in psychiatric disorders: Current evidence on fecal microbiota transplantation
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  contributor:
    fullname: Gasbarrini
– volume: 13
  year: 2021
  ident: bib25
  article-title: Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression
  publication-title: Nutrients
  contributor:
    fullname: Herbet
– volume: 310
  start-page: 459
  year: 2022
  end-page: 471
  ident: bib47
  article-title: Exploring the potential antidepressant mechanisms of puerarin: Anti-inflammatory response via the gut-brain axis
  publication-title: J. Affect. Disord.
  contributor:
    fullname: Ma
– volume: 10
  start-page: 925
  year: 2019
  end-page: 937
  ident: bib40
  article-title: Supplementation with Lactobacillus kefiranofaciens ZW3 from Tibetan Kefir improves depression-like behavior in stressed mice by modulating the gut microbiota
  publication-title: Food Funct.
  contributor:
    fullname: Wang
– volume: 151
  start-page: 363
  issue: 4
  year: 2017
  ident: 10.1016/j.biopha.2023.115679_bib49
  article-title: The immune response to Prevotella bacteria in chronic inflammatory disease
  publication-title: Immunology
  doi: 10.1111/imm.12760
  contributor:
    fullname: Larsen
– volume: 70
  start-page: 652
  year: 2007
  ident: 10.1016/j.biopha.2023.115679_bib14
  article-title: Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models
  publication-title: J. Nat. Prod.
  doi: 10.1021/np060470s
  contributor:
    fullname: Zhou
– volume: 526
  start-page: 225
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib50
  article-title: Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2021.11.027
  contributor:
    fullname: Hou
– volume: 40
  start-page: 336
  issue: 3
  year: 2019
  ident: 10.1016/j.biopha.2023.115679_bib65
  article-title: Integrating endocannabinoid signaling in the regulation of anxiety and depression
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/s41401-018-0051-5
  contributor:
    fullname: Yin
– volume: 102
  start-page: 5074
  issue: 14
  year: 2005
  ident: 10.1016/j.biopha.2023.115679_bib36
  article-title: Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0501526102
  contributor:
    fullname: Cox
– volume: 16
  start-page: 289
  issue: 2
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib28
  article-title: Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics
  publication-title: Autophagy
  doi: 10.1080/15548627.2019.1607686
  contributor:
    fullname: Thangaraj
– volume: 60
  start-page: 351
  issue: 3
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib58
  article-title: Umair, Lipids as biomarkers of brain disorders
  publication-title: Crit. Rev. Food Sci. Nutr.
  doi: 10.1080/10408398.2018.1529653
  contributor:
    fullname: Hussain
– volume: 11
  start-page: 6148
  issue: 7
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib67
  article-title: Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota
  publication-title: Food Funct.
  doi: 10.1039/D0FO00373E
  contributor:
    fullname: Gu
– volume: 44
  start-page: 569
  issue: 5
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib6
  article-title: Gut instincts in neuroimmunity from the eighteenth to twenty-first centuries
  publication-title: Semin. Immunopathol.
  doi: 10.1007/s00281-022-00948-2
  contributor:
    fullname: Nguyen
– volume: 88
  start-page: 161
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib66
  article-title: Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia
  publication-title: Brain, Behav., Immun.
  doi: 10.1016/j.bbi.2020.03.015
  contributor:
    fullname: Bekhbat
– volume: 31
  start-page: 109
  issue: 2
  year: 2013
  ident: 10.1016/j.biopha.2023.115679_bib13
  article-title: Neuroprotective effects of bacopaside I in ischemic brain injury
  publication-title: Restor. Neurol. Neurosci.
  contributor:
    fullname: Liu
– volume: 13
  start-page: 4020
  issue: 11
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib53
  article-title: Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A Randomized Controlled Trial
  publication-title: Nutrients
  doi: 10.3390/nu13114020
  contributor:
    fullname: Johnston
– volume: 172
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib26
  article-title: The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2021.105840
  contributor:
    fullname: Socala
– volume: 9
  start-page: 1239
  issue: 5
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib64
  article-title: Anxiety and depression are related to higher activity of sphingolipid metabolizing enzymes in the rat brain
  publication-title: Cells
  doi: 10.3390/cells9051239
  contributor:
    fullname: Zoicas
– volume: 12
  year: 2017
  ident: 10.1016/j.biopha.2023.115679_bib17
  article-title: Quantitation of Bacopaside I in Rat Biological Samples by LC-QTOF-MS/MS and Its Pharmacokinetic Application
  publication-title: Nat. Prod. Commun.
  contributor:
    fullname: Sookying
– volume: 10
  start-page: 19917
  issue: 1
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib56
  article-title: Intravenous administration of sodium propionate induces antidepressant or prodepressant effect in a dose dependent manner
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-77085-z
  contributor:
    fullname: Hao
– volume: 13
  issue: 3
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib25
  article-title: Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression
  publication-title: Nutrients
  doi: 10.3390/nu13030927
  contributor:
    fullname: Trzeciak
– volume: 147
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib62
  article-title: Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2022.112668
  contributor:
    fullname: Tayab
– volume: 12
  start-page: 528
  issue: 1
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib35
  article-title: PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-04489-w
  contributor:
    fullname: Tamargo
– volume: 11
  start-page: 25
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib12
  article-title: The role of short-chain fatty acids from gut microbiota in gut-brain communication
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2020.00025
  contributor:
    fullname: Silva
– volume: 16
  start-page: 75
  issue: 1
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib27
  article-title: Constitutive activity of serotonin receptor 6 regulates human cerebral organoids formation and depression-like behaviors
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2020.11.015
  contributor:
    fullname: Wang
– volume: 5
  start-page: 36
  issue: 1
  year: 2017
  ident: 10.1016/j.biopha.2023.115679_bib33
  article-title: Proteobacteria explain significant functional variability in the human gut microbiome
  publication-title: Microbiome
  doi: 10.1186/s40168-017-0244-z
  contributor:
    fullname: Bradley
– volume: 14
  start-page: 325
  issue: 5–6
  year: 2013
  ident: 10.1016/j.biopha.2023.115679_bib37
  article-title: Is exposure to cyanobacteria an environmental risk factor for amyotrophic lateral sclerosis and other neurodegenerative diseases?
  publication-title: Amyotroph. Lateral Scler. Front. Degener.
  doi: 10.3109/21678421.2012.750364
  contributor:
    fullname: Bradley
– volume: 144
  start-page: 427
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib75
  article-title: Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2019.12.138
  contributor:
    fullname: Yan
– volume: 22
  start-page: 527
  issue: 4
  year: 2017
  ident: 10.1016/j.biopha.2023.115679_bib21
  article-title: HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2016.120
  contributor:
    fullname: Keller
– volume: 10
  start-page: 925
  issue: 2
  year: 2019
  ident: 10.1016/j.biopha.2023.115679_bib40
  article-title: Supplementation with Lactobacillus kefiranofaciens ZW3 from Tibetan Kefir improves depression-like behavior in stressed mice by modulating the gut microbiota
  publication-title: Food Funct.
  doi: 10.1039/C8FO02096E
  contributor:
    fullname: Sun
– volume: 310
  start-page: 459
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib47
  article-title: Exploring the potential antidepressant mechanisms of puerarin: Anti-inflammatory response via the gut-brain axis
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2022.05.044
  contributor:
    fullname: Song
– volume: 23
  start-page: 2013
  issue: 4
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib29
  article-title: The Effects of Stress and Diet on the "Brain-Gut" and "Gut-Brain" Pathways in Animal Models of Stress and Depression
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms23042013
  contributor:
    fullname: Herselman
– volume: 70
  start-page: 490
  issue: 13
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib3
  article-title: Symptoms of anxiety or depressive disorder and use of mental health care among adults during the COVID-19 Pandemic - United States, August 2020-February 2021
  publication-title: Morb. Mortal. Wkly. Rep.
  doi: 10.15585/mmwr.mm7013e2
  contributor:
    fullname: Vahratian
– volume: 27
  start-page: 1222
  year: 2018
  ident: 10.1016/j.biopha.2023.115679_bib19
  article-title: Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2018.05.006
  contributor:
    fullname: Cignarella
– volume: 24
  start-page: 159
  year: 2017
  ident: 10.1016/j.biopha.2023.115679_bib41
  article-title: G. Probiotic in Pregnancy Study, Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2017.09.013
  contributor:
    fullname: Slykerman
– volume: 16
  start-page: 461
  issue: 8
  year: 2019
  ident: 10.1016/j.biopha.2023.115679_bib51
  article-title: The role of short-chain fatty acids in microbiota-gut-brain communication
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-019-0157-3
  contributor:
    fullname: Dalile
– volume: 12
  start-page: 65
  year: 2015
  ident: 10.1016/j.biopha.2023.115679_bib22
  article-title: Chronic intestinal inflammation alters hippocampal neurogenesis
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-015-0281-0
  contributor:
    fullname: Zonis
– volume: 2016
  start-page: 9890141
  year: 2016
  ident: 10.1016/j.biopha.2023.115679_bib63
  article-title: Sphingolipids as mediators in the crosstalk between microbiota and intestinal cells: implications for inflammatory bowel disease
  publication-title: Mediat. Inflamm.
  doi: 10.1155/2016/9890141
  contributor:
    fullname: Bryan
– volume: 6
  start-page: 30046
  year: 2016
  ident: 10.1016/j.biopha.2023.115679_bib44
  article-title: Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish
  publication-title: Sci. Rep.
  doi: 10.1038/srep30046
  contributor:
    fullname: Borrelli
– volume: 28
  start-page: 1443
  issue: 9
  year: 2018
  ident: 10.1016/j.biopha.2023.115679_bib68
  article-title: Lactobacillus johnsonii CJLJ103 Attenuates Scopolamine-Induced Memory Impairment in Mice by Increasing BDNF Expression and Inhibiting NF-kappaB
  publication-title: Act., J. Microbiol. Biotechnol.
  doi: 10.4014/jmb.1805.05025
  contributor:
    fullname: Lee
– volume: 2
  start-page: 16065
  year: 2016
  ident: 10.1016/j.biopha.2023.115679_bib1
  article-title: Major depressive disorder
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/nrdp.2016.65
  contributor:
    fullname: Otte
– volume: 12
  start-page: 13274
  issue: 1
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib42
  article-title: Investigation of memory-enhancing effects of Streptococcus thermophilus EG007 in mice and elucidating molecular and metagenomic characteristics using nanopore sequencing
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-022-14837-z
  contributor:
    fullname: Kim
– volume: 83
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib48
  article-title: The gut microbiota in anxiety and depression - A systematic review
  publication-title: Clin. Psychol. Rev.
  doi: 10.1016/j.cpr.2020.101943
  contributor:
    fullname: Simpson
– volume: 105
  start-page: 15570
  issue: 40
  year: 2008
  ident: 10.1016/j.biopha.2023.115679_bib59
  article-title: Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0803702105
  contributor:
    fullname: Bergami
– volume: 1027
  start-page: 103
  year: 2016
  ident: 10.1016/j.biopha.2023.115679_bib16
  article-title: A simple LC-ESI-MS/MS method for quantification of bacopaside I in rat plasma and its application to a pharmacokinetic study
  publication-title: J. Chromatogr. B
  doi: 10.1016/j.jchromb.2016.05.031
  contributor:
    fullname: Yin
– volume: 374
  start-page: 1087
  issue: 6571
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib31
  article-title: Signaling inflammation across the gut-brain axis
  publication-title: Science
  doi: 10.1126/science.abi6087
  contributor:
    fullname: Agirman
– volume: 12
  start-page: 74
  issue: 1
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib11
  article-title: Changes in gut viral and bacterial species correlate with altered 1,2-diacylglyceride levels and structure in the prefrontal cortex in a depression-like non-human primate model
  publication-title: Transl. Psychiatry
  doi: 10.1038/s41398-022-01836-x
  contributor:
    fullname: Wu
– volume: 71
  start-page: 1588
  issue: 8
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib8
  article-title: Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder
  publication-title: Gut
  contributor:
    fullname: Lou
– volume: 109
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib72
  article-title: Gut microbiota alteration and modulation in psychiatric disorders: Current evidence on fecal microbiota transplantation
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2021.110258
  contributor:
    fullname: Settanni
– volume: 8
  start-page: 1670
  year: 2017
  ident: 10.1016/j.biopha.2023.115679_bib57
  article-title: Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.01670
  contributor:
    fullname: Frye
– volume: 21
  start-page: 786
  issue: 6
  year: 2016
  ident: 10.1016/j.biopha.2023.115679_bib10
  article-title: Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2016.44
  contributor:
    fullname: Zheng
– volume: 21
  start-page: 145
  issue: 1
  year: 2023
  ident: 10.1016/j.biopha.2023.115679_bib18
  article-title: Matrine alleviates depressive-like behaviors via modulating microbiota-gut-brain axis in CUMS-induced mice
  publication-title: J. Transl. Med
  doi: 10.1186/s12967-023-03993-z
  contributor:
    fullname: Zhang
– volume: 13
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib71
  article-title: Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression-Case Report
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2022.815422
  contributor:
    fullname: Doll
– volume: 78
  start-page: 1233
  issue: 4
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib30
  article-title: TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-020-03656-y
  contributor:
    fullname: Ciesielska
– volume: 12
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib61
  article-title: Antidepressant Mechanism of Traditional Chinese Medicine Formula Xiaoyaosan in CUMS-Induced Depressed Mouse Model via RIPK1-RIPK3-MLKL Mediated Necroptosis Based on Network Pharmacology Analysis
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2021.773562
  contributor:
    fullname: Yan
– volume: 18
  start-page: 168
  issue: 3
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib5
  article-title: An overview of the heterogeneity of major depressive disorder: current knowledge and future prospective
  publication-title: Curr. Neuropharmacol.
  doi: 10.2174/1570159X17666191001142934
  contributor:
    fullname: Athira
– volume: 11
  start-page: 541
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib9
  article-title: Altered Composition of Gut Microbiota in Depression: A Systematic Review
  publication-title: Front. Psychiatry
  doi: 10.3389/fpsyt.2020.00541
  contributor:
    fullname: Barandouzi
– volume: 202
  start-page: 254
  year: 2016
  ident: 10.1016/j.biopha.2023.115679_bib39
  article-title: Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2016.05.038
  contributor:
    fullname: Aizawa
– volume: 1
  start-page: 399
  year: 1965
  ident: 10.1016/j.biopha.2023.115679_bib7
  article-title: Treatment of hepatic encephalopathy by alteration of intestinal flora with lactobacillus acidophilus
  publication-title: Lancet
  doi: 10.1016/S0140-6736(65)90002-4
  contributor:
    fullname: Macbeth
– volume: 88
  start-page: 308
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib32
  article-title: Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults
  publication-title: Brain, Behav., Immun.
  doi: 10.1016/j.bbi.2020.03.026
  contributor:
    fullname: Liu
– volume: 24
  start-page: 513
  issue: 3
  year: 2019
  ident: 10.1016/j.biopha.2023.115679_bib43
  article-title: of Exopolysaccharide Produced by Streptococcus thermophilus in the Intestinal Inflammation and Mucosal Barrier in Caco-2 Monolayer and Dextran Sulphate Sodium-Induced Experimental Murine Colitis
  publication-title: Molecules
  doi: 10.3390/molecules24030513
  contributor:
    fullname: Chen
– volume: 67
  start-page: 534
  issue: 3
  year: 2018
  ident: 10.1016/j.biopha.2023.115679_bib20
  article-title: Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy
  publication-title: Gut
  doi: 10.1136/gutjnl-2016-313332
  contributor:
    fullname: Tang
– volume: 17
  start-page: 1130
  issue: 11
  year: 2012
  ident: 10.1016/j.biopha.2023.115679_bib60
  article-title: Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2011.113
  contributor:
    fullname: Guilloux
– volume: 19
  start-page: 132
  issue: 1
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib24
  article-title: Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression
  publication-title: J. Neuroinflamm.
  doi: 10.1186/s12974-022-02492-0
  contributor:
    fullname: Wang
– volume: 281
  start-page: 51
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib52
  article-title: Acetate supplementation produces antidepressant-like effect via enhanced histone acetylation
  publication-title: J. Affect. Disord.
  doi: 10.1016/j.jad.2020.11.121
  contributor:
    fullname: Huang
– volume: 12
  issue: 1
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib38
  article-title: The combination of living Bifidobacterium, Lactobacillus, and Streptococcus improves social ranking and relieves anxiety-like behaviors in competitive mice in a social dominance tube test
  publication-title: Brain Behav.
  doi: 10.1002/brb3.2453
  contributor:
    fullname: Xie
– volume: 10
  start-page: 346
  issue: 1
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib74
  article-title: Integrated phosphoproteomic and metabolomic profiling reveals perturbed pathways in the hippocampus of gut microbiota dysbiosis mice
  publication-title: Transl. Psychiatry
  doi: 10.1038/s41398-020-01024-9
  contributor:
    fullname: Wang
– volume: 27
  start-page: 1920
  issue: 4
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib45
  article-title: A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia
  publication-title: Mol. Psychiatry
  doi: 10.1038/s41380-022-01456-3
  contributor:
    fullname: McGuinness
– volume: 34
  start-page: 33
  issue: 1
  year: 2022
  ident: 10.1016/j.biopha.2023.115679_bib46
  article-title: The intestinal microbiota as a predictor for antidepressant treatment outcome in geriatric depression: a prospective pilot study
  publication-title: Int. Psychogeriatr.
  doi: 10.1017/S1041610221000120
  contributor:
    fullname: Lee
– volume: 13
  start-page: 5
  issue: 1
  year: 2023
  ident: 10.1016/j.biopha.2023.115679_bib23
  article-title: Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression
  publication-title: Transl. Psychiatry
  doi: 10.1038/s41398-022-02297-y
  contributor:
    fullname: Guo
– volume: 42
  start-page: 3233
  issue: 11
  year: 2017
  ident: 10.1016/j.biopha.2023.115679_bib15
  article-title: Antidepressant-like Effect of Bacopaside I in Mice Exposed to Chronic Unpredictable Mild Stress by Modulating the Hypothalamic-Pituitary-Adrenal Axis Function and Activating BDNF Signaling Pathway
  publication-title: Neurochem. Res.
  doi: 10.1007/s11064-017-2360-3
  contributor:
    fullname: Zu
– volume: 102
  start-page: 37
  issue: 1
  year: 2019
  ident: 10.1016/j.biopha.2023.115679_bib69
  article-title: Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis
  publication-title: J. Dairy Sci.
  doi: 10.3168/jds.2018-14520
  contributor:
    fullname: Wasilewska
– volume: 97
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib54
  article-title: Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats
  publication-title: Prog. Neuro-Psychopharmacol. Biol. Psychiatry
  doi: 10.1016/j.pnpbp.2019.109794
  contributor:
    fullname: Meeking
– volume: 139
  start-page: 1407
  year: 2019
  ident: 10.1016/j.biopha.2023.115679_bib55
  article-title: Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.118.036652
  contributor:
    fullname: Bartolomaeus
– volume: 14
  start-page: 906
  issue: 4
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib34
  article-title: Novel syntrophic bacteria in full-scale anaerobic digesters revealed by genome-centric metatranscriptomics
  publication-title: ISME J.
  doi: 10.1038/s41396-019-0571-0
  contributor:
    fullname: Hao
– volume: 46
  start-page: 1613
  issue: 8
  year: 2016
  ident: 10.1016/j.biopha.2023.115679_bib2
  article-title: Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies
  publication-title: Psychol. Med
  doi: 10.1017/S0033291715002081
  contributor:
    fullname: Demirkan
– volume: 11
  start-page: 568
  issue: 1
  year: 2021
  ident: 10.1016/j.biopha.2023.115679_bib73
  article-title: Proteomics analysis of the gut-brain axis in a gut microbiota-dysbiosis model of depression
  publication-title: Transl. Psychiatry
  doi: 10.1038/s41398-021-01689-w
  contributor:
    fullname: Liu
– volume: 12
  start-page: 1
  issue: 1
  year: 2020
  ident: 10.1016/j.biopha.2023.115679_bib70
  article-title: Efficacy and safety of fecal microbiota transplantation for the treatment of diseases other than Clostridium difficile infection: a systematic review and meta-analysis
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2020.1854640
  contributor:
    fullname: Green
SSID ssj0005638
Score 2.4415348
Snippet Bacopaside I (BSI) is a natural compound that is difficult to absorb orally but has been shown to have antidepressant effects. The microbiota-gut-brain axis is...
SourceID doaj
proquest
crossref
pubmed
elsevier
SourceType Open Website
Aggregation Database
Index Database
Publisher
StartPage 115679
SubjectTerms Acetates - pharmacology
Animals
Antidepressive Agents - pharmacology
Antidepressive Agents - therapeutic use
Bacopaside I
Depression
Depression - metabolism
Fecal microbiota transplantation
Gastrointestinal Microbiome
Hypothalamo-Hypophyseal System
Lipidomics
Mice
Microbiota-gut-brain axis
Pituitary-Adrenal System
Short-chain fatty acids
Stress, Psychological - metabolism
SummonAdditionalLinks – databaseName: Elsevier SD Freedom Collection Journals【Remote access available】
  dbid: AIKHN
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9swFBZdC2MvY-tu2Q0NRp8qktiSbT22YSXdSCm0gb4J3RzU1XZonELon-85vjTrwxjszRbHtqxzJH1H50bId2NSIZx2TCcjx3ikOdNSapbZJEqldD7zqCjOzpLpnP-8Elc7ZNLHwqBbZbf2t2t6s1p3LcNuNIfLEIYXsNnFMRoKUCsAFPOM7KGRCDSwvaPTX9OzradH0hS0RnqGD_QRdI2blwkV5mXCKuKwfIgEfbr-2KGaRP5PNqq_AdFmQzp5RV52SJIetZ19TXZ8uU-ezzpb-T45OG-zUm8O6eU2yGp1SA_o-TZf9eYNuT-Gy6XGup30lGJtlbuACJT2XrJ3nt2E3572If0raja0qFxT-atcUMCQdLGuaRHarE6Fp7p0FONHaOFrELObsCpoKOlkPrtgoXQgTw7J_VsyP_lxOZmyriYDszzldXO0yQ3qkWMboxEudsKngLLG3IjMwVhLlwPmkVJ4K9woM2Obc5sBitD5GNjzjuyWVek_EApUGc_jzOYwUXMTaW-si6SXEmBY4uIBYT0f1LJNvaF6n7Rr1fJNId9Uy7cBOUZmPdJi4uymobpdqE5yFMgfICAthXWCw0_oyI7SJHVJnjqns9GApD2r1RM5hFeFf3z-Wy8ZCqYo2l106av1SkUS8yCgJjkg71uReewkAKZxnMTRx__-7ifyAu54eyz0mezWt2v_BYBSbb52E-EBQFMQFw
  priority: 102
  providerName: Elsevier
Title Bacopaside I alleviates depressive-like behaviors by modulating the gut microbiome and host metabolism in CUMS-induced mice
URI https://dx.doi.org/10.1016/j.biopha.2023.115679
https://www.ncbi.nlm.nih.gov/pubmed/38113632
https://search.proquest.com/docview/2904154161
https://doaj.org/article/799901a95cd54611a2c0767d6f7dda80
Volume 170
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9RAEF-0gvgitn6d2mME6VNXm2Q3yT62R8tVubNgDw5flv1KiTa54uUKh-Df7mw2ubYP0hffkrBJhsxs5je7M78h5IPWGedWWarSA0tZrBhVQiiamzTOhLAudz5QnEzT8Yx9nvP5rVZfPics0AOHD_cJb0CXpQQ3lrM0ilRsMPTObFpk1qo8ROvRJpjqkzvStoc1-sOEJmizfdFcm9mly4WnYvKNw_GPwVOfxnXLKbXc_Xd807-wZ-uDTp6Rpx14hMMg9DZ54Ood8njSbY_vkL2zQES93ofzm7qq5T7swdkNRfX6Ofl9hIdXyrfqhFPw7VSuSw86oU-MvXb0svzpoK_iX4JeQ7WwbbOv-gIQNsLFqoGqDEROlQNVW_AlI1C5Bi3rslxWUNYwmk2-UQz80YSsH-5ekNnJ8floTLs2DNSwjDXtaibTPnSMTOL33RLLXYbAKmKa5xa_tbAFwhwhuDPcHuQ6MgUzOQIHVUToJF-SrXpRu9cEcFTOiiQ3Bc7NQsfKaWNj4YRA5JXaZEBorwd5Fdg2ZJ-G9kMGvUmvNxn0NiBHXlmbsZ4ru72AFiQ7C5L3WdCAZL2qZQc7ApzAR5X3vP59bxkSZ6XfalG1W6yWMhae-sAHjwPyKpjMRkjESFGSJvGb_yH8W_IEBWJhUegd2Wp-rdwuwqRGD8nDj3-iIXl0ePplPB228wPPpqP51-9_AXsVEW4
link.rule.ids 315,786,790,870,2113,4516,24137,27946,27947,45609,45703
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ZaxsxEBZpCm1eSpteTi8VSp6ieg_tocfGNDhtHAKxIW9C1xq12V0T2wFT6G_vzB45Hkqhb4t2WGk1I8030hyEfNI6SxKrLFNpYBmPFGdKCMVyk0aZENblDg3FyWk6nvFvF8nFFhn1sTDoVtnt_e2e3uzWXcuwm83hwvvhOSi7OMaLArQKAMU8IA8BDQQo2p9_3_HzSJty1kjNkLyPn2ucvLSvMSsT1hCHzSNJ0aPrjn5q0vjfU1N_g6GNOjp6Sp50OJJ-aYf6jGy5apc8mnQ35btk_6zNSb05oNPbEKvlAd2nZ7fZqjfPya9DeFworNpJjylWVrn2iD9p7yN77dil_-loH9C_pHpDy9o2db-qOQUESefrFS19m9OpdFRVlmL0CC3dCoTs0i9L6is6mk3Oma8sSJNFcveCzI6-Tkdj1lVkYIZnfNUcbHKNVmRoYryCi23iMsBYIddJbmGuhS0A8QiROJPYINehKbjJAUOoIgR9-ZJsV3XlXhMKVDkv4twUsEwLHSmnjY2EEwJAWGrjAWE9H-SiTbwhe4-0H7Llm0S-yZZvA3KIzLqhxbTZTUN9NZed3EiQPsA_SiTGJhx-QkUmyNLMpkVmrcqDAcl6Vst7Ugif8v_o_mMvGRIWKN66qMrV66WMBGZBQDtyQF61InMzSIBLYZzG0d5_9_uBPB5PJyfy5Pj0-xuyA294e0D0lmyvrtbuHUCmlX7fLIk_Cz4R6A
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Bacopaside+I+alleviates+depressive-like+behaviors+by+modulating+the+gut+microbiome+and+host+metabolism+in+CUMS-induced+mice&rft.jtitle=Biomedicine+%26+pharmacotherapy&rft.au=Wang%2C+Jie&rft.au=Xin%2C+Jiayun&rft.au=Xu%2C+Xike&rft.au=Chen%2C+Wei&rft.date=2024-01-01&rft.issn=0753-3322&rft.volume=170&rft.spage=115679&rft_id=info:doi/10.1016%2Fj.biopha.2023.115679&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_biopha_2023_115679
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0753-3322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0753-3322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0753-3322&client=summon