HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

• Published in: Cell reports (Cambridge) Vol. 33; no. 10; p. 108487
• Main Authors: Zhao, Youbo, Li, Menghuan, Yao, Xuemei, Fei, Yang, Lin, Zhenghong, Li, Zhengguo, Cai, Kaiyong, Zhao, Yanli, Luo, Zhong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.12.2020
• Subjects: ferroptosis; lactate; MCT1; tumor microenvironment; tumor therapy; ferroptosis; tumor microenvironment; lactate; tumor therapy; MCT1

Ferroptosis is a recently discovered form of programed cell death caused by the metabolically regulated lipid peroxidation and holds promise for cancer treatment, but its regulatory mechanisms remain elusive. In this study, we observe that lactate-rich liver cancer cells exhibit enhanced resistance...