T-cell surveillance of the human brain in health and multiple sclerosis
Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central n...
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| Published in | Seminars in immunopathology Vol. 44; no. 6; pp. 855 - 867 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.11.2022
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central nervous system (CNS). In recent years, beneficial as well as occasional, detrimental effects of T-cell-targeting drugs in people with early multiple sclerosis (MS) have increased interest in T cells patrolling the CNS. Next to studies focusing on T cells in the cerebrospinal fluid, phenotypic characteristics of T cells located in the perivascular space and the meninges as well as in the parenchyma in MS lesions have been reported. We here summarize the current knowledge about T cells infiltrating the healthy and MS brain and argue that understanding the dynamics of physiological CNS surveillance by T cells is likely to improve the understanding of pathological conditions, such as MS. |
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| AbstractList | Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central nervous system (CNS). In recent years, beneficial as well as occasional, detrimental effects of T-cell-targeting drugs in people with early multiple sclerosis (MS) have increased interest in T cells patrolling the CNS. Next to studies focusing on T cells in the cerebrospinal fluid, phenotypic characteristics of T cells located in the perivascular space and the meninges as well as in the parenchyma in MS lesions have been reported. We here summarize the current knowledge about T cells infiltrating the healthy and MS brain and argue that understanding the dynamics of physiological CNS surveillance by T cells is likely to improve the understanding of pathological conditions, such as MS. Abstract Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central nervous system (CNS). In recent years, beneficial as well as occasional, detrimental effects of T-cell-targeting drugs in people with early multiple sclerosis (MS) have increased interest in T cells patrolling the CNS. Next to studies focusing on T cells in the cerebrospinal fluid, phenotypic characteristics of T cells located in the perivascular space and the meninges as well as in the parenchyma in MS lesions have been reported. We here summarize the current knowledge about T cells infiltrating the healthy and MS brain and argue that understanding the dynamics of physiological CNS surveillance by T cells is likely to improve the understanding of pathological conditions, such as MS. |
| Author | Hsiao, Cheng-Chih Smolders, Joost van Luijn, Marvin M. Hamann, Jörg |
| Author_xml | – sequence: 1 givenname: Joost orcidid: 0000-0001-9766-8661 surname: Smolders fullname: Smolders, Joost email: j.j.f.m.smolders@erasmusmc.nl organization: Neuroimmunology Research Group, Netherlands Institute for Neuroscience, MS Center ErasMS, Departments of Neurology and Immunology, Erasmus Medical Center – sequence: 2 givenname: Marvin M. orcidid: 0000-0002-1283-1018 surname: van Luijn fullname: van Luijn, Marvin M. organization: MS Center ErasMS, Department of Immunology, Erasmus Medical Center – sequence: 3 givenname: Cheng-Chih orcidid: 0000-0003-3572-1046 surname: Hsiao fullname: Hsiao, Cheng-Chih organization: Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Department of Experimental Immunology, Amsterdam institute for Infection and Immunity, Amsterdam University Medical Centers – sequence: 4 givenname: Jörg orcidid: 0000-0002-9448-1727 surname: Hamann fullname: Hamann, Jörg email: j.hamann@amsterdamumc.nl organization: Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Department of Experimental Immunology, Amsterdam institute for Infection and Immunity, Amsterdam University Medical Centers |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35364699$$D View this record in MEDLINE/PubMed |
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| Keywords | perivascular space cells T multiple sclerosis cerebrospinal fluid CNS meninges TRM cells |
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| SubjectTerms | Biomedical and Life Sciences Biomedicine Brain Central Nervous System Cerebrospinal fluid Drug delivery Humans Immunology Internal Medicine Lymphocytes Lymphocytes T Meninges Multiple sclerosis Multiple Sclerosis - pathology Parenchyma Pathology Review Surveillance T-Lymphocytes |
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| Title | T-cell surveillance of the human brain in health and multiple sclerosis |
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