Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia

• Published in: Brain Structure and Function Vol. 227; no. 9; pp. 3043 - 3061
• Main Authors: Souter, Nicholas E., Wang, Xiuyi, Thompson, Hannah, Krieger-Redwood, Katya, Halai, Ajay D., Lambon Ralph, Matthew A., Thiebaut de Schotten, Michel, Jefferies, Elizabeth
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2022; Springer Nature B.V
• Subjects: Aphasia; Aphasia - diagnosis; Aphasia - etiology; Aphasia - pathology; Biomedical and Life Sciences; Biomedicine; Brain Mapping; Cell Biology; Cerebral hemispheres; Cerebral infarction; Cognition & reasoning; Cognitive ability; Corpus callosum; Cortex (frontal); Cortex (temporal); Executive function; Frontal gyrus; Hemispheric laterality; Humans; Lesions; Magnetic Resonance Imaging - methods; Neurology; Neurosciences; Original; Original Article; Semantics; Stroke; Structure-function relationships; Substantia alba; Temporal Lobe - pathology; Functional; Aphasia; Stroke; Semantic; Structural; Disconnection
• ISSN: 1863-2653; 1863-2661; 1863-2661; 0340-2061
• DOI: 10.1007/s00429-022-02526-6

Patients with semantic aphasia have impaired control of semantic retrieval, often accompanied by executive dysfunction following left hemisphere stroke. Many but not all of these patients have damage to the left inferior frontal gyrus, important for semantic and cognitive control. Yet semantic and c...