Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun/HIF-1α signaling

• Published in: Archives of toxicology Vol. 93; no. 6; pp. 1543 - 1553
• Main Authors: Ichihara, Sahoko, Li, Ping, Mise, Nathan, Suzuki, Yuka, Izuoka, Kiyora, Nakajima, Tamie, Gonzalez, Frank, Ichihara, Gaku
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2019; Springer Nature B.V
• Subjects: Ablation; AhR gene; Angiotensin; Angiotensin II; Angiotensin II - toxicity; Animals; Aromatic compounds; Aromatic hydrocarbons; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biomedical and Life Sciences; Biomedicine; Blood pressure; Blood Pressure - drug effects; c-Jun protein; Deoxyribonucleic acid; DNA; Endothelins; Environmental Health; Fenofibrate; Fenofibrate - pharmacology; Fibrosis; Growth factors; Halogenated hydrocarbons; Heart; Hydrocarbons; Hypertrophy; Hypertrophy, Left Ventricular - pathology; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-inducible factors; JNK Mitogen-Activated Protein Kinases - genetics; Ligands; Male; Mice; Mice, Knockout; Molecular Toxicology; Myocardium - pathology; Occupational Medicine/Industrial Medicine; Pharmacology/Toxicology; PPAR alpha - agonists; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - metabolism; Rodents; Signal transduction; Signal Transduction - drug effects; Signal Transduction - genetics; Signaling; Transcription factors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - biosynthesis; Vascular Endothelial Growth Factor A - genetics; Ventricle; Xenobiotics; Fibrosis; Cardiac hypertrophy; HIF-1α; AHR; Angiotensin II; PPARα; Vascular endothelial growth factor

Aryl hydrocarbon receptor (AHR) is a transcription factor that binds to DNA as a heterodimer with the AHR nuclear translocator (ARNT) after interaction with ligands, such as polycyclic and halogenated aromatic hydrocarbons and other xenobiotics. The endogenous ligands and functions of AHR have been...