Triclosan induces liver injury in long-life exposed mice via activation of TLR4/NF-κB/NLRP3 pathway

• Published in: Ecotoxicology and environmental safety Vol. 273; p. 116115
• Main Authors: Peng, Yuxuan, Cui, He, Shu, Chang, Wei, Ziyun, Ni, Xiao, Liu, Jieyu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.03.2024; Elsevier
• Subjects: Animals; Humans; Inflammasomes - metabolism; Liver - metabolism; Liver injury; Long-life exposed model; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - metabolism; NF-kappa B - genetics; NF-kappa B - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; TLR4/NF-κB/NLRP3; TNF Receptor-Associated Factor 6 - metabolism; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; Triclosan; Triclosan - toxicity; Long-life exposed model; Triclosan; TLR4/NF-κB/NLRP3; Liver injury

Triclosan (TCS) is a widely used synthetic, with broad-spectrum antibacterial properties found in both pharmaceuticals and personal care products. More specifically, it is hepatotoxic in rodents and exhibits differential effects in mice and humans. However, the mechanisms underlying TCS-induced live...