Sex-dependent dynamics of metabolism in primary mouse hepatocytes

• Published in: Archives of toxicology Vol. 95; no. 9; pp. 3001 - 3013
• Main Authors: Hochmuth, Luise, Körner, Christiane, Ott, Fritzi, Volke, Daniela, Cokan, Kaja Blagotinšek, Juvan, Peter, Brosch, Mario, Hofmann, Ute, Hoffmann, Ralf, Rozman, Damjana, Berg, Thomas, Matz-Soja, Madlen
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2021; Springer Nature B.V
• Subjects: Amino acids; Animals; Aryl Hydrocarbon Hydroxylases - genetics; Biomedical and Life Sciences; Biomedicine; Clinical trials; Cytochrome P-450 Enzyme System - genetics; Cytochrome P450 Family 2 - genetics; Degradation; Drug metabolism; Drugs; Environmental Health; Fatty liver; Female; Gene expression; Gene Expression Regulation - physiology; Health services; Hepatocellular carcinoma; Hepatocytes; Hepatocytes - metabolism; Lipid metabolism; Lipids; Liver; Liver cancer; Liver diseases; Male; Males; Melatonin; Melatonin - metabolism; Metabolic pathways; Metabolism; Metabolome - physiology; Mice; Mice, Inbred C57BL; Occupational Medicine/Industrial Medicine; Organs; Oxidation; Pharmacodynamics; Pharmacology; Pharmacology/Toxicology; Proteome - physiology; Proteomes; Serotonin; Serotonin - metabolism; Sex Characteristics; Sex Factors; Sexual dimorphism; Signal transduction; Signal Transduction - physiology; Signaling; Steatosis; Steroid Hydroxylases - genetics; Toxicokinetics and Metabolism; Transcriptome - physiology; Transcriptomes; Drug metabolism; Sexual dimorphism; Lipid metabolism; Hepatocytes; Liver; Cytochrome P450

The liver is one of the most sexually dimorphic organs. The hepatic metabolic pathways that are subject to sexual dimorphism include xenobiotic, amino acid and lipid metabolism. Non-alcoholic fatty liver disease and hepatocellular carcinoma are among diseases with sex-dependent prevalence, progressi...