Cortical diffusivity investigation in posterior cortical atrophy and typical Alzheimer’s disease

• Published in: Journal of neurology Vol. 268; no. 1; pp. 227 - 239
• Main Authors: Torso, Mario, Ahmed, Samrah, Butler, Christopher, Zamboni, Giovanna, Jenkinson, Mark, Chance, Steven
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021; Springer Nature B.V
• Subjects: Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Alzheimer's disease; Atrophy; Atrophy - pathology; Cerebral cortex; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cortex (parietal); Dementia; Dementia disorders; Differential diagnosis; Diffusion Tensor Imaging; Humans; Investigations; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Neurodegeneration; Neurodegenerative diseases; Neuroimaging; Neurology; Neuroradiology; Neurosciences; Occipital lobe; Original Communication; Temporal cortex; Temporal lobe; Typical Alzheimer’s disease; Minicolumn; Posterior cortical atrophy; Cortical diffusivity; Diffusion tensor imaging

Objectives To investigate the global cortical and regional quantitative features of cortical neural architecture in the brains of patients with posterior cortical atrophy (PCA) and typical Alzheimer’s disease (tAD) compared with elderly healthy controls (HC). Methods A novel diffusion MRI method, th...