Blood-brain barrier regulation in psychiatric disorders

• Published in: Neuroscience letters Vol. 726; p. 133664
• Main Authors: Kealy, John, Greene, Chris, Campbell, Matthew
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.05.2020
• Subjects: Animals; Autism spectrum disorder; Biological Transport - physiology; Blood-Brain Barrier - diagnostic imaging; Blood-Brain Barrier - metabolism; Brain - diagnostic imaging; Brain - metabolism; Claudin-5; Depression; Endothelial cell; Endothelial Cells - metabolism; Humans; Inflammation Mediators - metabolism; Mental Disorders - diagnostic imaging; Mental Disorders - metabolism; Mental Disorders - psychology; Neuroimaging - methods; Neuroimaging - trends; Permeability; Schizophrenia; Tight junction; Tight Junctions - metabolism; Endothelial cell; BBB; DCE-MRI; CBF; Schizophrenia; CNS; AQP4; ICAM-1; MDD; NVU; ASD; VE-Cadherin; SNP; CK-BB; CSF; NMDA; MBP; TBI; TM4; PECAM; GLUT1; NSE; IL; QAlb; EEG; VEGF; Claudin-5; Depression; Autism spectrum disorder; GFAP; VCAM-1; FRA; TNF-α; ZO; JAM; PGP; 22q11DS; Tight junction; ESAM; MMP-9; TIMP

•The blood-brain barrier (BBB) forms a critical interface between the brain and blood circulation.•Loss of BBB integrity appears to be a common pathological finding in many psychiatric disorders including schizophrenia, autism spectrum disorder (ASD) and mood disorders.•BBB dysfunction leads to infi...