Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

• Published in: Developmental cell Vol. 51; no. 5; pp. 575 - 586.e4
• Main Authors: Brown, Caitlin W., Amante, John J., Chhoy, Peter, Elaimy, Ameer L., Liu, Haibo, Zhu, Lihua Julie, Baer, Christina E., Dixon, Scott J., Mercurio, Arthur M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.12.2019
• Subjects: breast cancer; Breast Neoplasms - metabolism; Carcinoma - metabolism; Cell Line; Cell Line, Tumor; Epithelial Cells - metabolism; Epithelial Cells - pathology; exosome; Extracellular Matrix - metabolism; Female; ferritin; Ferritins - metabolism; Ferroptosis; GPX4; Humans; iron; Iron - metabolism; mammary gland; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Multivesicular Bodies - metabolism; multivesicular body; Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism; prominin2; therapy; ferritin; ferroptosis; GPX4; therapy; multivesicular body; iron; breast cancer; mammary gland; prominin2; exosome

Ferroptosis, regulated cell death characterized by the iron-dependent accumulation of lethal lipid reactive oxygen species, contributes to tissue homeostasis and numerous pathologies, and it may be exploited for therapy. Cells differ in their sensitivity to ferroptosis, however, and a key challenge...