Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

• Published in: Cell reports (Cambridge) Vol. 27; no. 4; pp. 1265 - 1276.e4
• Main Authors: Saito, Yoshimasa, Muramatsu, Toshihide, Kanai, Yae, Ojima, Hidenori, Sukeda, Aoi, Hiraoka, Nobuyoshi, Arai, Eri, Sugiyama, Yuko, Matsuzaki, Juntaro, Uchida, Ryoei, Yoshikawa, Nao, Furukawa, Ryo, Saito, Hidetsugu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.04.2019
• Subjects: antifungal drug; biliary tract carcinoma; drug screening; gallbladder cancer; intrahepatic cholangiocarcinoma; neuroendocrine carcinoma of the ampulla of Vater; organoid culture; gallbladder cancer; neuroendocrine carcinoma of the ampulla of Vater; drug screening; organoid culture; biliary tract carcinoma; antifungal drug; intrahepatic cholangiocarcinoma

Biliary tract carcinomas (BTCs) are among the most aggressive malignancies and have a poor prognosis. Here, we successfully established organoid lines derived from intrahepatic cholangiocarcinoma, gallbladder cancer, and neuroendocrine carcinoma of the ampulla of Vater. These organoids derived from...