On the sulfation of O-desmethyltramadol by human cytosolic sulfotransferases

• Published in: Pharmacological reports Vol. 69; no. 5; pp. 953 - 958
• Main Authors: Rasool, Mohammed I., Bairam, Ahsan F., Kurogi, Katsuhisa, Liu, Ming-Cheh
• Format: Journal Article
• Language: English
• Published: Cham Elsevier Urban & Partner Sp. z o.o 01.10.2017; Springer International Publishing
• Subjects: Caco-2 Cells; Cytosol - enzymology; Cytosolic sulfotransferase; Drug Safety and Pharmacovigilance; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Intestine, Small - cytology; Kidney - cytology; Liver - cytology; Lung - cytology; Molecular Structure; O-Desmethyltramadol; Original Article; Pharmacotherapy; Pharmacy; Sulfation; Sulfotransferases - metabolism; SULT; Tramadol; Tramadol - analogs & derivatives; Tramadol - chemistry; Tramadol - metabolism; PAPS; Cytosolic sulfotransferase; O-DMT; Tramadol; O-Desmethyltramadol; TLC; ATP; SULT; Sulfation; Desmethyltramadol

[Display omitted] Previous studies have demonstrated that sulfate conjugation is involved in the metabolism of the active metabolite of tramadol, O-desmethyltramadol (O-DMT). The current study aimed to systematically identify the human cytosolic sulfotransferases (SULTs) that are capable of mediatin...