Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

• Published in: Cell reports (Cambridge) Vol. 28; no. 13; pp. 3309 - 3319.e5
• Main Authors: Petrie, Emma J., Sandow, Jarrod J., Lehmann, Wil I.L., Liang, Lung-Yu, Coursier, Diane, Young, Samuel N., Kersten, Wilhelmus J.A., Fitzgibbon, Cheree, Samson, André L., Jacobsen, Annette V., Lowes, Kym N., Au, Amanda E., Jousset Sabroux, Hélène, Lalaoui, Najoua, Webb, Andrew I., Lessene, Guillaume, Manning, Gerard, Lucet, Isabelle S., Murphy, James M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.09.2019; Elsevier
• Subjects: innate immunity; MLKL; necroptosis; poxvirus; programmed necrosis; pseudokinase; RIPK3; programmed necrosis; innate immunity; MLKL; RIPK3; poxvirus; pseudokinase; necroptosis

Necroptotic cell death has been implicated in many human pathologies and is thought to have evolved as an innate immunity mechanism. The pathway relies on two key effectors: the kinase receptor-interacting protein kinase 3 (RIPK3) and the terminal effector, the pseudokinase mixed-lineage kinase-doma...