Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

• Published in: Nature microbiology Vol. 7; no. 5; pp. 663 - 674
• Main Authors: Rhodes, Johanna, Abdolrasouli, Alireza, Dunne, Katie, Sewell, Thomas R., Zhang, Yuyi, Ballard, Eloise, Brackin, Amelie P., van Rhijn, Norman, Chown, Harry, Tsitsopoulou, Alexandra, Posso, Raquel B., Chotirmall, Sanjay H., McElvaney, Noel G., Murphy, Philip G., Talento, Alida Fe, Renwick, Julie, Dyer, Paul S., Szekely, Adrien, Bowyer, Paul, Bromley, Michael J., Johnson, Elizabeth M., Lewis White, P., Warris, Adilia, Barton, Richard C., Schelenz, Silke, Rogers, Thomas R., Armstrong-James, Darius, Fisher, Matthew C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2022; Nature Publishing Group
• Subjects: 45/22; 45/23; 45/43; 631/181/457/649/2219; 631/208/212/2304; Anti-Infective Agents; Aspergillus fumigatus; Aspergillus fumigatus - genetics; Azoles - pharmacology; Biomedical and Life Sciences; Clinical isolates; Drug resistance; Drug Resistance, Fungal - genetics; Ergosterol; Fungicides; Genetic analysis; Genomes; Genomic analysis; Genomics; Genotypes; Humans; Infections; Infectious Diseases; Life Sciences; Medical Microbiology; Metagenomics; Microbial Sensitivity Tests; Microbiology; Parasitology; Patients; Polygenic inheritance; Positive selection; Recombination; Respiratory tract diseases; Virology; Whole genome sequencing

Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to first-line azole antifungal drugs. However, despite its clinical importance, little is known about how susceptible patients acquire infection from drug-resistant genotypes in the environment. Here, we presen...