Immunophenotyping monocytes, macrophages and granulocytes in the Pteropodid bat Eonycteris spelaea

• Published in: Scientific reports Vol. 10; no. 1; p. 309
• Main Authors: Gamage, Akshamal M., Zhu, Feng, Ahn, Matae, Foo, Randy Jee Hiang, Hey, Ying Ying, Low, Dolyce H. W., Mendenhall, Ian H., Dutertre, Charles-Antoine, Wang, Lin-Fa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.01.2020; Nature Publishing Group
• Subjects: 13/106; 13/31; 38/77; 631/250/255/2514; 631/250/262; Animals; Antigens, CD - metabolism; Antigens, Differentiation, Myelomonocytic - metabolism; Bone marrow; CD11b antigen; CD14 antigen; CD163 antigen; CD44 antigen; Cell Differentiation - drug effects; Chiroptera; Chiroptera - classification; Chiroptera - genetics; Chiroptera - immunology; Chiroptera - virology; Comparative studies; Disease tolerance; Eonycteris spelaea; Gene Expression - drug effects; Genome; Genomes; Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology; Granulocytes; Granulocytes - cytology; Granulocytes - metabolism; Humanities and Social Sciences; Humans; Immunological tolerance; Immunophenotyping - methods; Interleukin-8 - genetics; Interleukin-8 - metabolism; Leukocytes (granulocytic); Lipopolysaccharides - pharmacology; Macrophages; Macrophages - cytology; Macrophages - drug effects; Macrophages - metabolism; Major histocompatibility complex; MARCO protein; Mice; Mice, Inbred C57BL; Monocytes; Monocytes - cytology; Monocytes - metabolism; multidisciplinary; Nectar; Phylogeny; Pteropodidae; Receptors, Cell Surface - metabolism; Science; Science (multidisciplinary); Surface markers; Transcription; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Viral diseases; Zoonoses

Bats are asymptomatic reservoir hosts for several highly pathogenic viruses. Understanding this enigmatic relationship between bats and emerging zoonotic viruses requires tools and approaches which enable the comparative study of bat immune cell populations and their functions. We show that bat geno...