Matrine induces papillary thyroid cancer cell apoptosis in vitro and suppresses tumor growth in vivo by downregulating miR-182-5p

• Published in: Biomedicine & pharmacotherapy Vol. 128; p. 110327
• Main Authors: Fu, Songbo, Zhao, Nan, Jing, Gaojing, Yang, Xiaomei, Liu, Jingfang, Zhen, Donghu, Tang, Xulei
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.08.2020; Elsevier
• Subjects: Alkaloids - pharmacology; Animals; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis; Apoptosis - drug effects; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Matrine; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; MiR-182-5p; Papillary thyroid cancer; Quinolizines - pharmacology; Signal Transduction; Thyroid Cancer, Papillary - drug therapy; Thyroid Cancer, Papillary - genetics; Thyroid Cancer, Papillary - metabolism; Thyroid Cancer, Papillary - pathology; Thyroid Neoplasms - drug therapy; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; Tumor Burden - drug effects; Xenograft Model Antitumor Assays; Matrine; Papillary thyroid cancer; MiR-182-5p; Apoptosis

[Display omitted] •Matrine inhibits miR-182-5p expression and induces apoptosis of PTC cells.•Overexpression of miR-182-5p abolishes the marine-induced apoptosis of PTC cells.•Matrine‑suppressed tumor growth were attenuated after miR-182-5p was overexpressed.•Matrine suppresses tumor growth in vivo...