Cord blood-derived endothelial colony-forming cell function is disrupted in congenital diaphragmatic hernia

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 310; no. 11; pp. L1143 - L1154
• Main Authors: Fujinaga, Hideshi, Fujinaga, Hiroko, Watanabe, Nobuyuki, Kato, Tomoko, Tamano, Moe, Terao, Miho, Takada, Shuji, Ito, Yushi, Umezawa, Akihiro, Kuroda, Masahiko
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2016
• Subjects: Blood; Case-Control Studies; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CXCL12 - blood; Endothelial Progenitor Cells - physiology; Endothelium; Fetal Blood; Growth kinetics; Hernias; Hernias, Diaphragmatic, Congenital - metabolism; Hernias, Diaphragmatic, Congenital - pathology; Humans; Infant, Newborn; Kinetics; Lungs; Neovascularization, Physiologic; Nitric Oxide; Vascular Endothelial Growth Factor A - physiology; congenital diaphragmatic hernia; cord blood; endothelial colony-forming cells; endothelial progenitor cells

Vascular growth is necessary for normal lung development. Although endothelial progenitor cells (EPCs) play an important role in vascularization, little is known about EPC function in congenital diaphragmatic hernia (CDH), a severe neonatal condition that is associated with pulmonary hypoplasia. We...