Lactylation: a Passing Fad or the Future of Posttranslational Modification

Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and disea...

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Published inInflammation Vol. 45; no. 4; pp. 1419 - 1429
Main Authors Xin, Qi, Wang, Hai, Li, Qinglin, Liu, Sinan, Qu, Kai, Liu, Chang, Zhang, Jingyao
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2022
Springer Nature B.V
Subjects
Adenosine triphosphate
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cell activation
Gene expression
Glycolysis
Histones
Histones - metabolism
Humans
Hypoxia
Immunology
Inflammation
Internal Medicine
Kinases
Lactates
Lactic acid
Macrophage Activation
Macrophages
Mammals
Metabolism
Metabolites
Pathology
Pharmacology/Toxicology
Physiology
Protein Processing, Post-Translational
Proteins
Review
Rheumatology
gene transcription
cancer
lactate
lactylation
inflammation
posttranslational modification
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Abstract Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies.
AbstractList Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies.Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies.
Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone proteins, i.e., a novel posttranslational modification. This review summarizes recent advances related to lactylation in lactate metabolism and diseases. Notably, lactylation plays a vital role in cancer, inflammation, and regeneration; however, the specific mechanism remains unclear. Histone lactylation regulates oncogenic processes by targeting gene transcription and inflammation via macrophage activation. Eventually, we identified research gaps and recommended several primary directions for further studies.
Author Qu, Kai
Liu, Sinan
Wang, Hai
Xin, Qi
Zhang, Jingyao
Li, Qinglin
Liu, Chang
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  organization: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University
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  organization: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University
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  organization: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University
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  organization: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Department of SICU, The First Affiliated Hospital of Xi’an Jiaotong University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35224683$$D View this record in MEDLINE/PubMed
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Issue 4
Keywords gene transcription
cancer
lactate
lactylation
inflammation
posttranslational modification
Language English
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  year: 2022
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  day: 01
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PublicationTitle Inflammation
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Springer Nature B.V
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Snippet Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene transcription via lactylation of histones and non-histone...
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SubjectTerms Adenosine triphosphate
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cancer
Cell activation
Gene expression
Glycolysis
Histones
Histones - metabolism
Humans
Hypoxia
Immunology
Inflammation
Internal Medicine
Kinases
Lactates
Lactic acid
Macrophage Activation
Macrophages
Mammals
Metabolism
Metabolites
Pathology
Pharmacology/Toxicology
Physiology
Protein Processing, Post-Translational
Proteins
Review
Rheumatology
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Title Lactylation: a Passing Fad or the Future of Posttranslational Modification
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