Lipid droplets and fatty acid‐induced lipotoxicity: in a nutshell

• Published in: FEBS letters Vol. 598; no. 10; pp. 1207 - 1214
• Main Authors: Obaseki, Eseiwi, Adebayo, Daniel, Bandyopadhyay, Sumit, Hariri, Hanaa
• Format: Journal Article
• Language: English
• Published: England 01.05.2024
• Subjects: Animals; autophagy; energy; fatty acid; Fatty Acids - metabolism; homeostasis; Humans; lipid droplet; Lipid Droplets - metabolism; Lipid Metabolism; lipids; lipolysis; lipophagy; lipotoxicity; organelles; lipid droplet; fatty acid; autophagy; lipolysis; lipophagy; lipotoxicity

Lipid droplets (LDs) are fat storage organelles that are conserved from bacteria to humans. LDs are broken down to supply cells with fatty acids (FAs) that can be used as an energy source or membrane synthesis. An overload of FAs disrupts cellular functions and causes lipotoxicity. Thus, by acting a...