Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients
Summary Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer patients is not established. We genotyped 101 cancer patients with VT and 101 cancer patients without VT for these polymorphisms. Fi...
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| Published in | British journal of haematology Vol. 128; no. 3; pp. 386 - 388 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.02.2005
Blackwell |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Summary
Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer patients is not established. We genotyped 101 cancer patients with VT and 101 cancer patients without VT for these polymorphisms. Five cases and three controls were heterozygous for FVL, yielding an odds ratio of 1·7 (95% confidence interval (CI) 0·3–10·7). Five cases and no controls were heterozygous for prothrombin 20210A, for an odds ratio of 6·7 (95% CI 0·9–infinity). Prothrombin 20210A may be associated with VT risk among cancer patients. |
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| AbstractList | Summary
Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer patients is not established. We genotyped 101 cancer patients with VT and 101 cancer patients without VT for these polymorphisms. Five cases and three controls were heterozygous for FVL, yielding an odds ratio of 1·7 (95% confidence interval (CI) 0·3–10·7). Five cases and no controls were heterozygous for prothrombin 20210A, for an odds ratio of 6·7 (95% CI 0·9–infinity). Prothrombin 20210A may be associated with VT risk among cancer patients. Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer patients is not established. We genotyped 101 cancer patients with VT and 101 cancer patients without VT for these polymorphisms. Five cases and three controls were heterozygous for FVL, yielding an odds ratio of 1.7 (95% confidence interval (CI) 0.3-10.7). Five cases and no controls were heterozygous for prothrombin 20210A, for an odds ratio of 6.7 (95% CI 0.9-infinity). Prothrombin 20210A may be associated with VT risk among cancer patients. |
| Author | Chassereau, Laurie Durda, Peter Kennedy, Margaret Thomas, Christian A. Greenblatt, Marc S. Andreescu, Astrid C. M. Jiang, Hongyu Wong, Cheung Cushman, Mary |
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| Keywords | Human Factor V Leiden Hematology Vein thrombosis Cardiovascular disease Malignant tumor Epidemiology Venous disease Vascular disease Thrombophilia prothrombin 20210A Risk factor Prothrombin Venous thrombosis cancer |
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Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT... Cancer patients have an increased risk of venous thrombosis (VT). The association of factor V Leiden (FVL) and the prothrombin 20210A variant with VT in cancer... |
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| SubjectTerms | Aged Biological and medical sciences Blood and lymphatic vessels cancer Cardiology. Vascular system Case-Control Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Factor V - genetics factor V Leiden Female Genetic Predisposition to Disease Hematologic and hematopoietic diseases Hematology Humans Male Medical sciences Middle Aged Neoplasms - complications Neoplasms - genetics Polymorphism, Genetic Prothrombin - genetics prothrombin 20210A risk factor Risk Factors venous thrombosis Venous Thrombosis - etiology Venous Thrombosis - genetics |
| Title | Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients |
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