Arabidopsis DNA ligase IV is induced by γ‐irradiation and interacts with an Arabidopsis homologue of the double strand break repair protein XRCC4

• Published in: The Plant journal : for cell and molecular biology Vol. 24; no. 1; pp. 67 - 78
• Main Authors: West, Christopher E., Waterworth, Wanda M., Jiang, Qing, Bray, Clifford M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.10.2000; Blackwell Science
• Subjects: Amino Acid Sequence; Arabidopsis - enzymology; Arabidopsis - genetics; Arabidopsis - radiation effects; Arabidopsis thaliana; AtLIG4 gene; Biological and medical sciences; BRCT domain; DNA Ligase ATP; DNA ligase IV; DNA Ligases - biosynthesis; DNA Ligases - genetics; DNA Ligases - metabolism; DNA Repair; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; Dose-Response Relationship, Radiation; double-strand break repair; Enzyme Induction - radiation effects; Enzymes; Fundamental and applied biological sciences. Psychology; Gamma Rays; Gene Expression Regulation, Enzymologic - radiation effects; Gene Expression Regulation, Plant - radiation effects; Humans; Light; Metabolism; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Molecular Weight; Mutagenesis. Repair; non‐homologous end joining; Plant physiology and development; Recombination, Genetic; Saccharomyces cerevisiae - enzymology; Sequence Alignment; Sequence Homology, Amino Acid; Ultraviolet Rays; XRCC4 protein; Enzyme; Induction; DNA binding protein; DNA ligase (ATP); Phosphoric ester ligases; Arabidopsis thaliana; Characterization; Double stranded DNA; Gamma irradiation; Cruciferae; Ligases; Dicotyledones; Angiospermae; Spermatophyta; Experimental plant; Molecular cloning; Repair; Molecular domain

Summary Rejoining of single‐ and double‐strand breaks (DSBs) introduced in DNA during replication, recombination, and DNA damage is catalysed by DNA ligase enzymes. Eukaryotes possess multiple DNA ligase enzymes, each having distinct roles in cellular metabolism. Double‐strand breaks in DNA, which c...