Fish oil supplementation reduces cortisol basal levels and perceived stress: A randomized, placebo-controlled trial in abstinent alcoholics

• Published in: Molecular nutrition & food research Vol. 57; no. 6; pp. 1110 - 1114
• Main Authors: Barbadoro, Pamela, Annino, Isidoro, Ponzio, Elisa, Romanelli, Roberto M. L., D'Errico, Marcello M., Prospero, Emilia, Minelli, Andrea
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.06.2013; Wiley
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Alcohol Abstinence - psychology; Alcoholism; Alcoholism - rehabilitation; Alcoholism and acute alcohol poisoning; Anxiety; Biological and medical sciences; Dietary Supplements; Docosahexaenoic acid; Docosahexaenoic Acids - pharmacology; Eicosapentaenoic acid; Eicosapentaenoic Acid - pharmacology; Feeding. Feeding behavior; Fish Oils - pharmacology; Fish Oils - therapeutic use; Fundamental and applied biological sciences. Psychology; Humans; Hydrocortisone - metabolism; Hypothalamic-Pituitary-Adrenocortical Axis; Male; Medical sciences; Psycho-social stress; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Saliva - drug effects; Saliva - metabolism; Stress, Psychological - diet therapy; Toxicology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Lipids; Docosahexaenoic acid; Hydrocortisone; n-3 fatty acid; Psycho-social stress; Randomization; Hypothalamic-Pituitary-Adrenocortical Axis; Disintoxication; Supplementation; Hypothalamohypophysocorticoadrenal axis; Corticosteroid; Poison withdrawal; Nutrition; Steroid hormone; Alcoholism; Antiinflammatory agent; Polyunsaturated fatty acid; Edible oil; Fish oil; Abstinence; Stress; Feeding; Addiction; Adrenal hormone; Eicosapentaenoic acid

Behavioral distress and dysfunctions of hypothalamic‐pituitary‐adrenocortical (HPA) axis play a central role in alcohol abuse. Omega‐3 fatty acids are proposed as having antistress, regulatory effects on HPA responsiveness, but a possible protective role in ethanol addiction is unexplored.A randomiz...