Neuropilin-2 Is Upregulated in Lung Cancer Cells during TGF-β1―Induced Epithelial-Mesenchymal Transition

• Published in: Cancer research (Chicago, Ill.) Vol. 73; no. 23; pp. 7111 - 7121
• Main Authors: NASARRE, Patrick, GEMMILL, Robert M, DRABKIN, Harry A, POTIRON, Vincent A, ROCHE, Joëlle, XIAN LU, BARON, Anna E, KORCH, Christopher, GARRETT-MAYER, Elizabeth, LAGANA, Alessandro, HOWE, Philip H
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.12.2013
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell Transformation, Neoplastic - drug effects; Cell Transformation, Neoplastic - genetics; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - genetics; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Medical sciences; Mice; Mice, Nude; Mice, Transgenic; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neuropilin-2 - genetics; Pharmacology. Drug treatments; Pneumology; Transforming Growth Factor beta1 - pharmacology; Tumor Cells, Cultured; Tumors; Tumors of the respiratory system and mediastinum; Up-Regulation; Lung disease; Respiratory disease; Lung cancer; Bronchus disease; Malignant tumor; Transforming growth factor β1; Epithelial mesenchymal transition; Cell transformation; Bronchopulmonary; Tumor cell; Cancer

The epithelial-mesenchymal transition (EMT) and its reversal, mesenchymal-epithelial transition (MET), are fundamental processes involved in tumor cell invasion and metastasis. SEMA3F is a secreted semaphorin and tumor suppressor downregulated by TGF-β1 and ZEB1-induced EMT. Here, we report that neu...