Bioinformatics Analysis and Immunogenicity Assessment of the Novel Multi‐Stage DNA Vaccine W541 Against Mycobacterium Tuberculosis

• Published in: Immunity, Inflammation and Disease Vol. 12; no. 11; pp. e70074 - n/a
• Main Authors: Yang, Yourong, Xue, Yong, Wang, Xiaoou, Wang, Lan, Wang, Jie, Zhang, Junxian, Liu, Yinping, Liang, Yan, Wu, Xueqiong
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.11.2024; John Wiley and Sons Inc; Wiley
• Subjects: Amino acids; Animal research; Animals; Antigens; Antigens, Bacterial - genetics; Antigens, Bacterial - immunology; bioinformatic analysis; Bioinformatics; Clinical trials; Computational Biology - methods; Cytotoxicity; DNA vaccine; Epitopes, B-Lymphocyte - genetics; Epitopes, B-Lymphocyte - immunology; Epitopes, T-Lymphocyte - immunology; Female; Hepatitis; Humans; Immunity (Disease); immunogenicity; Immunogenicity, Vaccine; Infections; Mice; Molecular Docking Simulation; Mycobacterium tuberculosis - immunology; Original; Peptides; Physicochemical properties; Prevention; Proteins; simulated immunization; Tuberculosis; Tuberculosis - immunology; Tuberculosis - prevention & control; Tuberculosis Vaccines - immunology; Vaccines; Vaccines, DNA - immunology; Virulence; DNA vaccine; simulated immunization; bioinformatic analysis; immunogenicity; tuberculosis

ABSTRACT Background Vaccination is one of the effective measures to prevent latent tuberculosis infection (LTBI) from developing into active tuberculosis (TB). Applying bioinformatics methods to pre‐evaluate the biological characteristics and immunogenicity of vaccines can improve the efficiency of...