Prefrontal Abnormality of Schizophrenia Revealed by DNA Microarray: Impact on Glial and Neurotrophic Gene Expression

• Published in: Annals of the New York Academy of Sciences Vol. 1025; no. 1; pp. 84 - 91
• Main Authors: SUGAI, TETSUJI, KAWAMURA, MEIKO, IRITANI, SHUJI, ARAKI, KAZUAKI, MAKIFUCHI, TAKAO, IMAI, CHINA, NAKAMURA, RYOSUKE, KAKITA, AKIYOSHI, TAKAHASHI, HITOSHI, NAWA, HIROYUKI
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2004
• Subjects: Aged; Animals; astrocyte; Gene Expression Profiling - methods; Gene Expression Regulation - physiology; growth factor; haloperidol; Humans; Macaca fascicularis; Middle Aged; Nerve Growth Factors - genetics; Nerve Growth Factors - metabolism; Neuroglia - metabolism; Neuroglia - pathology; oligodendrocyte; Oligonucleotide Array Sequence Analysis - methods; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; psychosis; Schizophrenia - genetics; Schizophrenia - metabolism; Schizophrenia - pathology

: DNA microarrays with isotope labeling from gene‐specific primers enable sensitive detection of rare mRNAs, including neurotrophin and cytokine mRNAs in the brain. Using high‐quality RNA from postmortem brains, gene‐expression profiles covering 1373 genes were assessed in the dorsoprefrontal cortex...