Light-Switchable Polymer from Cationic to Zwitterionic Form: Synthesis, Characterization, and Interactions with DNA and Bacterial Cells

• Published in: Macromolecular rapid communications. Vol. 34; no. 8; pp. 635 - 639
• Main Authors: Sobolčiak, Patrik, Špírek, Mário, Katrlík, Jaroslav, Gemeiner, Peter, Lacík, Igor, Kasák, Peter
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 25.04.2013; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Subjects: Acrylamides - chemistry; antibacterial; Applied sciences; carboxybetaine ester; Cations - chemistry; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - metabolism; dsDNA polyplex; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - metabolism; Exact sciences and technology; Free Radicals - chemistry; Light; Organic polymers; photochemistry; Photolysis; Physicochemistry of polymers; Polymers; Polymers - chemical synthesis; Polymers - chemistry; Polymers - pharmacology; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; Proteins; Quaternary Ammonium Compounds - chemistry; Surface Plasmon Resonance; water-soluble polymers; Biological properties; Nitro compound; Polyplex; dsDNA polyplex; Drug carrier; antibacterial; Photochemical reaction; Double stranded DNA; Binding capacity; Debenzylation; Release; Carboxylate polymer; Polyampholyte; Control release polymer; Photoinduced effect; carboxybetaine ester; Bactericidal effect; Methacrylamide derivative polymer; Polyelectrolyte; Chemical modification; Free radical polymerization; Light sensitive polymer; photochemistry; Preparation; water-soluble polymers; Kinetics; Aqueous solution; Antibacterial agent; Quaternary ammonium polymer

A novel cationic polymer poly(N,N‐dimethyl‐N‐[3‐(methacroylamino) propyl]‐N‐[2‐[(2‐nitrophenyl)methoxy]‐2‐oxo‐ethyl]ammonium chloride) is synthesized by free‐radical polymerization of N‐[3‐(dimethylamino)propyl] methacrylamide and subsequent quaternization with o‐nitrobenzyl 2‐chloroacetate. The pho...