Developing multicomponent interventions using fractional factorial designs

Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refining such multicomponent interventions is to start with a large number of pot...

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Published inStatistics in medicine Vol. 28; no. 21; pp. 2687 - 2708
Main Authors Chakraborty, Bibhas, Collins, Linda M., Strecher, Victor J., Murphy, Susan A.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 20.09.2009
Wiley Subscription Services, Inc
Subjects
experimental design
Factor Analysis, Statistical
Factorial experiments
Follow-Up Studies
fractional factorial design
Health sciences
Humans
Intervention
Mass Screening
Models, Statistical
multicomponent intervention
Research Design
screening
Simulation
Smoking cessation
Smoking Cessation - methods
Smoking Cessation - statistics & numerical data
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Abstract Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refining such multicomponent interventions is to start with a large number of potential components and screen out the least active ones. Factorial designs can be used efficiently in this endeavor. We address common criticisms and misconceptions regarding the use of factorial designs in these screening studies. We also provide an operationalization of screening studies. As an example, we consider the use of a screening study in the development of a multicomponent smoking cessation intervention. Simulation results are provided to support the discussions. Copyright © 2009 John Wiley & Sons, Ltd.
AbstractList Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refining such multicomponent interventions is to start with a large number of potential components and screen out the least active ones. Factorial designs can be used efficiently in this endeavor. We address common criticisms and misconceptions regarding the use of factorial designs in these screening studies. We also provide an operationalization of screening studies. As an example, we consider the use of a screening study in the development of a multicomponent smoking cessation intervention. Simulation results are provided to support the discussions.
Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refining such multicomponent interventions is to start with a large number of potential components and screen out the least active ones. Factorial designs can be used efficiently in this endeavor. We address common criticisms and misconceptions regarding the use of factorial designs in these screening studies. We also provide an operationalization of screening studies. As an example, we consider the use of a screening study in the development of a multicomponent smoking cessation intervention. Simulation results are provided to support the discussions. [PUBLICATION ABSTRACT]
Abstract Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refining such multicomponent interventions is to start with a large number of potential components and screen out the least active ones. Factorial designs can be used efficiently in this endeavor. We address common criticisms and misconceptions regarding the use of factorial designs in these screening studies. We also provide an operationalization of screening studies. As an example, we consider the use of a screening study in the development of a multicomponent smoking cessation intervention. Simulation results are provided to support the discussions. Copyright © 2009 John Wiley & Sons, Ltd.
Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refiing such multicomponent interventions is to start with a large number of potential components and screen out the least active ones. Factorial designs can be used efficiently in this endeavor. We address common criticisms and misconceptions regarding the use of factorial designs in these screening studies. We also provide an operationalization of screening studies. As an example we consider the use of a screening study in the development of a multicomponent smoking cessation intervention. Simulation results are provided to support the discussions.
Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health sciences. A natural experimental approach to developing and refining such multicomponent interventions is to start with a large number of potential components and screen out the least active ones. Factorial designs can be used efficiently in this endeavor. We address common criticisms and misconceptions regarding the use of factorial designs in these screening studies. We also provide an operationalization of screening studies. As an example, we consider the use of a screening study in the development of a multicomponent smoking cessation intervention. Simulation results are provided to support the discussions. Copyright © 2009 John Wiley & Sons, Ltd.
Author Strecher, Victor J.
Chakraborty, Bibhas
Murphy, Susan A.
Collins, Linda M.
AuthorAffiliation 1 Department of Statistics and The Institute for Social Research, University of Michigan
2 The Methodology Center and Department of Human Development and Family Studies, Pennsylvania State University
3 Center for Health Communications Research, University of Michigan
AuthorAffiliation_xml – name: 3 Center for Health Communications Research, University of Michigan
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  givenname: Susan A.
  surname: Murphy
  fullname: Murphy, Susan A.
  organization: Department of Statistics and The Institute for Social Research, University of Michigan, Ann Arbor, MI, U.S.A
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Cites_doi 10.1136/bmj.321.7262.694
10.1093/oxfordjournals.aje.a008940
10.1097/01.qai.0000219771.97303.0a
10.1191/1740774505cn067oa
10.1007/BF00941505
10.1177/1740774508100973
10.1016/j.jsp.2006.01.005
10.1111/j.1360-0443.2005.01093.x
10.1016/j.jadohealth.2005.09.013
10.1016/j.amepre.2007.12.024
10.1002/sim.4780080204
10.1002/clc.4960291403
10.1080/01621459.1986.10478354
10.2307/1912934
10.2105/AJPH.2007.127563
10.1207/s15324796abm3001_8
10.1200/JCO.2002.03.003
10.1177/0002716205274941
10.1037/h0037350
10.15288/jsas.2005.s15.34
10.1080/00224065.1981.11978747
10.1002/sim.4780121708
10.2307/3151144
10.1080/00401706.1996.10484538
10.1080/01621459.1984.10478078
10.1037/10222-006
10.1037/a0015826
10.1056/NEJM199409293311301
10.1016/j.genhosppsych.2006.12.003
10.1002/0471740136
10.1136/bmj.316.7131.611
10.15288/jsas.2005.s15.24
10.1037/0022-006X.66.3.549
10.1080/09540269874907
10.1186/1472-6963-7-136
10.2307/1266725
10.1136/tc.2003.006189
10.1002/sim.4780090112
10.1007/BF00942173
10.1038/oby.2007.163
10.1016/S0738-3991(98)00128-1
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References Collins L, Chakraborty B, Murphy S, Strecher V. Comparison of a phased experimental approach and a single randomized clinical trial for developing multicomponent behavioral interventions. Clinical Trials 2009; 6(1):5-15.
Collins L, Murphy S, Nair V, Strecher V. A strategy for optimizing and evaluating behavioral interventions. Annals of Behavioral Medicine 2005; 30:65-73.
Green S, Liu P, O'Sullivan J. Factorial design considerations. Journal of Clinical Oncology 2002; 20(16):3424-3430.
Dijkstra A, DeVries H, Roijackers J, Van Breukelen G. Tailored interventions to communicate stage-matched information to smokers in different motivational stages. Journal of Consulting and Clinical Psychology 1998; 66(3):549-557.
Strecher V. Computer-tailored smoking cessation materials: a review and discussion. Patient Education and Counselling 1999; 36:107-117.
Myers R, Montgomery D. Response Surface Methodology. Wiley: New York, 1995.
Flay B, Collins L. Historical review of school-based randomized trials for evaluating problem behavior prevention programs. Annals of the American Academy of Political and Social Science 2005; 599:115-146.
Tinetti M, McAvary G, Claus E. Does multiple risk factor reduction explain the reduction in fall rate in the Yale FICSIT trial? American Journal of Epidemiology 1996; 144:389-399.
Tinetti M, Baker D, McAvary G, Claus E, Garrett P, Gottschalk M, Koch M, Trainor K, Horwitz R. A multifactorial intervention to reduce the risk of falling among elderly people living in the community. New England Journal of Medicine 1994; 331:821-827.
West S, Aiken L, Todd M. Probing the effects of individual components in multiple component prevention programs. American Journal of Community Psychology 1993; 21(5):571-605.
Meyer R, Steinberg D, Box G. Follow-up designs to resolve confounding in multifactor experiments. Technometrics 1996; 38:303-332.
Cuffe M. The patient with cardiovascular disease: treatment strategies for preventing major events. Clinical Cardiology 2006; 29(II):4-12.
Montgomery A, Peters T, Little P. Design, analysis and presentation of factorial randomized controlled trials. BMC Medical Research Methodology 2003; 3(26):14633287.
Box G, Hunter J. The 2k−p fractional factorial designs. Technometrics 1961; 3:311-351 and 449-458.
Byar D. Factorial and reciprocal control designs (with Discussion). Statistics in Medicine 1990; 9:55-64.
White H. A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity. Econometrica 1980; 48:817-838.
Daunica A, Smitha S, Branka E, Penfield R. Classroom-based cognitive-behavioral intervention to prevent aggression: efficacy and social validity. Journal of School Psychology 2006; 44(2):123-139.
Couper D, Hosking J, Cisler R, Gastfriend D, Kivlahan D. Factorial designs in clinical trials: options for combination treatment studies. Journal of Studies on Alcohol 2005; S15:24-32.
Box G, Draper N. Empirical Model-building and Response Surfaces. Wiley: New York, 1987.
Nair V, Strecher V, Fagerlin A, Ubel P, Resnicow K, Murphy S, Little R, Chakraborty B, Zhang A. Screening experiments and fractional factorial designs in behavioral intervention research. American Journal of Public Health 2008; 98:1354-1359.
Allore H, Tinettia M, Gill T, Peduzzi P. Experimental designs for multicomponent interventions among persons with multifactorial geriatric syndromes. Clinical Trials 2005; 2(1):13-21.
Bluford D, Sherry B, Scanlon K. Interventions to prevent or treat obesity in preschool children: a review of evaluated programs. Obesity 2007; 15:1356-1372.
Wu C, Hamada M. Experiments: Planning, Analysis, and Parameter Design Optimization. Wiley: New York, 2000.
Campbell M, Fitzpatrick R, Haines A, Kinmonth A, Sandercock P, Spiegelhalter D, Tyrer P. Framework for design and evaluation of complex interventions to improve health. British Medical Journal 2000; 321:694-696.
Brittain E, Wittes J. Factorial designs in clinical trials: the effects of non-compliance and subadditivity. Statistics in Medicine 1989; 8:161-171.
Swartz L, Noell J, Schroeder S, Ary D. A randomized control study of a fully automated internet based smoking cessation programme. Tobacco Control 2006; 15:7-12.
Collins L, Dziak J, Li R. Design of experiments with multiple independent variables: a resource management perspective on complete and reduced factorial designs. Psychological Methods 2009; 14.
Hosking J, Cisler R, Couper D, Gastfriend D, Kivlahan D, Anton R. Design and analysis of trials of combination therapies. Journal of Studies on Alcohol 2005; S15:34-42.
Paul G, Smith S, Whitford D, O'Kelly F, O'Dowd T. Development of a complex intervention to test the effectiveness of peer support in type 2 diabetes. BMC Health Services Research 2007; 7:136.
Fisher R. The Design of Experiments (3rd edn). Oliver & Boyd: Edinburgh, 1942.
Cohen J. Statistical Power for the Behavioral Sciences (2nd edn). Erlbaum: Hillsdale, NJ, 1988.
Strecher V, McClure J, Alexander G, Chakraborty B, Nair V, Konkel J, Greene S, Collins L, Carlier C, Wiese C, Little R, Pomerleau C, Pomerleau O. Web-based smoking cessation components and tailoring depth: results of a randomized trial. American Journal of Preventive Medicine 2008; 34(5):373-381.
Smith J, Beverly J. The use and analysis of staggered nested factorial designs. Journal of Quality Technology 1981; 13:166-173.
Friedli K, King M. Psychological treatments and their evaluation. International Review of Psychiatry 1998; 10:123-126.
Stephenson J, Imrie J. Why do we need randomised controlled trials to assess behavioural interventions? British Medical Journal 1998; 316:611-613.
Byar D, Piantadosi S. Factorial designs for randomized clinical trials. Cancer Treatment Reports 1985; 69:1055-1063.
Golin C, Earp J, Tien H, Stewart P, Porter C, Howie L. A 2-arm, randomized, controlled trial of a motivational interviewing-based intervention to improve adherence to antiretroviral therapy (ART) among patients failing or initiating ART. Journal of Acquired Immune Deficiency Syndrome 2006; 42:42-51.
Wolchik S, West S, Westover S, Sandler I, Martin A, Lustig J, Tein J, Fisher J. The children of divorce intervention project: outcome evaluation of an empirically based parenting program. American Journal of Community Psychology 1993; 21:293-331.
Byar D, Herzberg A, Tan W. Incomplete factorial designs for randomized clinical trials. Statistics in Medicine 1993; 12:1629-1641.
Strecher V, Shiffman S, West R. Randomized controlled trial of a web-based computer-tailored smoking cessation program as a supplement to nicotine patch therapy. Addiction 2005; 100:682-688.
Searle S, Casella G, McCulloch C. Variance Components. Wiley: New York, 2002.
Rosenbaum P, Rubin D. Reducing bias in observational studies using subclassification on the propensity score. Journal of the American Statistical Association 1984; 79:516-524.
Riggs N, Elfenbaum P, Pentz M. Parent program component analysis in a drug abuse prevention trial. Journal of Adolescent Health 2006; 39:66-72.
Ankerman B, Aviles A, Pinheiro J. Optimal designs for mixed-effects models with two random nested factors. Statistica Sinica 2003; 13:385-401.
Williams J, Gerrity M, Holsinger T, Dobscha S, Gaynes B, Dietrich A. Systematic review of multifaceted interventions to improve depression care. General Hospital Psychiatry 2007; 29:91-116.
Piantadosi S. Clinical Trials: A Methodologic Perspective. Wiley: New York, 2005.
Curhan R. The effects of merchandising and temporary promotional activities on the sales of fresh fruits and vegetables in supermarkets. Journal of Marketing Research 1974; 11(3):286-294.
Box G, Hunter W, Hunter J. Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building. Wiley: New York, 1978.
Rubin D. Estimating causal effects of treatments in randomized and nonrandomized studies. Journal of Educational Psychology 1974; 66:688-701.
Holland P. Statistics and causal inference. Journal of the American Statistical Association 1986; 81:945-970.
1980; 48
1994; 331
1974; 11
2006; 39
1993; 21
2003; 13
1998; 316
2008; 34
1996; 144
1996; 38
1937
1978
1985; 69
2007; 29
2009; 14
1986; 81
2000
2005; 100
1961; 3
1987
2005; 30
1942
2003; 3
1986
2006; 29
2007; 7
2000; 321
1998; 10
1988
2005; 599
1989; 8
2006; 15
1997
1995
2008; 98
2005
2002
1998; 66
2007; 15
1993; 12
2006; 42
1974; 66
2002; 20
2006; 44
2005; S15
1984; 79
1999; 36
1981; 13
2009; 6
2005; 2
1990; 9
17436821 - Clin Cardiol. 2006 Oct;29(10 Suppl):II4-12
16223053 - J Stud Alcohol Suppl. 2005 Jul;(15):24-32; discussion 6-7
8192123 - Am J Community Psychol. 1993 Oct;21(5):571-605
8078528 - N Engl J Med. 1994 Sep 29;331(13):821-7
10987780 - BMJ. 2000 Sep 16;321(7262):694-6
4042085 - Cancer Treat Rep. 1985 Oct;69(10):1055-63
12177102 - J Clin Oncol. 2002 Aug 15;20(16):3424-30
14633287 - BMC Med Res Methodol. 2003 Nov 24;3:26
8235181 - Stat Med. 1993 Sep 15;12(17):1629-41
17336659 - Gen Hosp Psychiatry. 2007 Mar-Apr;29(2):91-116
9642894 - J Consult Clin Psychol. 1998 Jun;66(3):549-57
18407003 - Am J Prev Med. 2008 May;34(5):373-81
16279575 - Clin Trials. 2005;2(1):13-21
16436397 - Tob Control. 2006 Feb;15(1):7-12
16097907 - Ann Behav Med. 2005 Aug;30(1):65-73
2345838 - Stat Med. 1990 Jan-Feb;9(1-2):55-63; discussion 63-4
16763491 - J Acquir Immune Defic Syndr. 2006 May;42(1):42-51
18556602 - Am J Public Health. 2008 Aug;98(8):1354-9
17557972 - Obesity (Silver Spring). 2007 Jun;15(6):1356-72
8311029 - Am J Community Psychol. 1993 Jun;21(3):293-31
8712196 - Am J Epidemiol. 1996 Aug 15;144(4):389-99
17764549 - BMC Health Serv Res. 2007;7:136
15847626 - Addiction. 2005 May;100(5):682-8
16223054 - J Stud Alcohol Suppl. 2005 Jul;(15):34-42; discussion 33
9518919 - BMJ. 1998 Feb 21;316(7131):611-3
10223016 - Patient Educ Couns. 1999 Feb;36(2):107-17
19254929 - Clin Trials. 2009 Feb;6(1):5-15
2704898 - Stat Med. 1989 Feb;8(2):161-71
19719358 - Psychol Methods. 2009 Sep;14(3):202-24
16781963 - J Adolesc Health. 2006 Jul;39(1):66-72
Searle S (e_1_2_1_52_2) 2002
Cuffe M (e_1_2_1_3_2) 2006; 29
Fisher R (e_1_2_1_18_2) 1942
e_1_2_1_41_2
Kazdin A (e_1_2_1_30_2) 1986
Wu C (e_1_2_1_19_2) 2000
e_1_2_1_22_2
e_1_2_1_45_2
e_1_2_1_20_2
e_1_2_1_43_2
e_1_2_1_26_2
Box G (e_1_2_1_14_2) 1978
e_1_2_1_24_2
e_1_2_1_47_2
e_1_2_1_28_2
Box G (e_1_2_1_48_2) 1987
e_1_2_1_6_2
e_1_2_1_54_2
e_1_2_1_4_2
Byar D (e_1_2_1_21_2) 1985; 69
e_1_2_1_2_2
e_1_2_1_12_2
e_1_2_1_33_2
e_1_2_1_10_2
e_1_2_1_31_2
e_1_2_1_16_2
e_1_2_1_37_2
Montgomery A (e_1_2_1_29_2) 2003; 3
e_1_2_1_35_2
Myers R (e_1_2_1_49_2) 1995
e_1_2_1_8_2
e_1_2_1_39_2
e_1_2_1_40_2
e_1_2_1_23_2
e_1_2_1_44_2
Smith J (e_1_2_1_50_2) 1981; 13
e_1_2_1_27_2
e_1_2_1_25_2
e_1_2_1_46_2
Ankerman B (e_1_2_1_51_2) 2003; 13
Cohen J (e_1_2_1_42_2) 1988
e_1_2_1_53_2
e_1_2_1_7_2
e_1_2_1_5_2
e_1_2_1_11_2
e_1_2_1_34_2
e_1_2_1_32_2
e_1_2_1_15_2
e_1_2_1_38_2
e_1_2_1_13_2
e_1_2_1_36_2
e_1_2_1_17_2
e_1_2_1_9_2
References_xml – volume: 15
  start-page: 7
  year: 2006
  end-page: 12
  article-title: A randomized control study of a fully automated internet based smoking cessation programme
  publication-title: Tobacco Control
– year: 1937
– year: 2005
– start-page: 23
  year: 1986
  end-page: 68
– volume: 21
  start-page: 293
  year: 1993
  end-page: 331
  article-title: The children of divorce intervention project: outcome evaluation of an empirically based parenting program
  publication-title: American Journal of Community Psychology
– volume: 39
  start-page: 66
  year: 2006
  end-page: 72
  article-title: Parent program component analysis in a drug abuse prevention trial
  publication-title: Journal of Adolescent Health
– volume: 38
  start-page: 303
  year: 1996
  end-page: 332
  article-title: Follow‐up designs to resolve confounding in multifactor experiments
  publication-title: Technometrics
– volume: 316
  start-page: 611
  year: 1998
  end-page: 613
  article-title: Why do we need randomised controlled trials to assess behavioural interventions?
  publication-title: British Medical Journal
– year: 1942
– volume: 20
  start-page: 3424
  issue: 16
  year: 2002
  end-page: 3430
  article-title: Factorial design considerations
  publication-title: Journal of Clinical Oncology
– volume: 34
  start-page: 373
  issue: 5
  year: 2008
  end-page: 381
  article-title: Web‐based smoking cessation components and tailoring depth: results of a randomized trial
  publication-title: American Journal of Preventive Medicine
– volume: 12
  start-page: 1629
  year: 1993
  end-page: 1641
  article-title: Incomplete factorial designs for randomized clinical trials
  publication-title: Statistics in Medicine
– volume: 331
  start-page: 821
  year: 1994
  end-page: 827
  article-title: A multifactorial intervention to reduce the risk of falling among elderly people living in the community
  publication-title: New England Journal of Medicine
– volume: 13
  start-page: 166
  year: 1981
  end-page: 173
  article-title: The use and analysis of staggered nested factorial designs
  publication-title: Journal of Quality Technology
– volume: 69
  start-page: 1055
  year: 1985
  end-page: 1063
  article-title: Factorial designs for randomized clinical trials
  publication-title: Cancer Treatment Reports
– volume: 21
  start-page: 571
  issue: 5
  year: 1993
  end-page: 605
  article-title: Probing the effects of individual components in multiple component prevention programs
  publication-title: American Journal of Community Psychology
– volume: 14
  year: 2009
  article-title: Design of experiments with multiple independent variables: a resource management perspective on complete and reduced factorial designs
  publication-title: Psychological Methods
– volume: 36
  start-page: 107
  year: 1999
  end-page: 117
  article-title: Computer‐tailored smoking cessation materials: a review and discussion
  publication-title: Patient Education and Counselling
– year: 1997
– volume: 66
  start-page: 549
  issue: 3
  year: 1998
  end-page: 557
  article-title: Tailored interventions to communicate stage‐matched information to smokers in different motivational stages
  publication-title: Journal of Consulting and Clinical Psychology
– volume: S15
  start-page: 24
  year: 2005
  end-page: 32
  article-title: Factorial designs in clinical trials: options for combination treatment studies
  publication-title: Journal of Studies on Alcohol
– volume: 321
  start-page: 694
  year: 2000
  end-page: 696
  article-title: Framework for design and evaluation of complex interventions to improve health
  publication-title: British Medical Journal
– volume: 30
  start-page: 65
  year: 2005
  end-page: 73
  article-title: A strategy for optimizing and evaluating behavioral interventions
  publication-title: Annals of Behavioral Medicine
– volume: 3
  start-page: 311
  year: 1961
  end-page: 351
  article-title: The 2 fractional factorial designs
  publication-title: Technometrics
– volume: 599
  start-page: 115
  year: 2005
  end-page: 146
  article-title: Historical review of school‐based randomized trials for evaluating problem behavior prevention programs
  publication-title: Annals of the American Academy of Political and Social Science
– volume: 81
  start-page: 945
  year: 1986
  end-page: 970
  article-title: Statistics and causal inference
  publication-title: Journal of the American Statistical Association
– volume: 2
  start-page: 13
  issue: 1
  year: 2005
  end-page: 21
  article-title: Experimental designs for multicomponent interventions among persons with multifactorial geriatric syndromes
  publication-title: Clinical Trials
– volume: 98
  start-page: 1354
  year: 2008
  end-page: 1359
  article-title: Screening experiments and fractional factorial designs in behavioral intervention research
  publication-title: American Journal of Public Health
– year: 1987
– volume: 10
  start-page: 123
  year: 1998
  end-page: 126
  article-title: Psychological treatments and their evaluation
  publication-title: International Review of Psychiatry
– year: 2000
– volume: 11
  start-page: 286
  issue: 3
  year: 1974
  end-page: 294
  article-title: The effects of merchandising and temporary promotional activities on the sales of fresh fruits and vegetables in supermarkets
  publication-title: Journal of Marketing Research
– volume: 7
  start-page: 136
  year: 2007
  article-title: Development of a complex intervention to test the effectiveness of peer support in type 2 diabetes
  publication-title: BMC Health Services Research
– volume: 9
  start-page: 55
  year: 1990
  end-page: 64
  article-title: Factorial and reciprocal control designs (with Discussion)
  publication-title: Statistics in Medicine
– volume: S15
  start-page: 34
  year: 2005
  end-page: 42
  article-title: Design and analysis of trials of combination therapies
  publication-title: Journal of Studies on Alcohol
– volume: 44
  start-page: 123
  issue: 2
  year: 2006
  end-page: 139
  article-title: Classroom‐based cognitive‐behavioral intervention to prevent aggression: efficacy and social validity
  publication-title: Journal of School Psychology
– volume: 29
  start-page: 4
  issue: II
  year: 2006
  end-page: 12
  article-title: The patient with cardiovascular disease: treatment strategies for preventing major events
  publication-title: Clinical Cardiology
– volume: 100
  start-page: 682
  year: 2005
  end-page: 688
  article-title: Randomized controlled trial of a web‐based computer‐tailored smoking cessation program as a supplement to nicotine patch therapy
  publication-title: Addiction
– year: 2002
– year: 1988
– volume: 6
  start-page: 5
  issue: 1
  year: 2009
  end-page: 15
  article-title: Comparison of a phased experimental approach and a single randomized clinical trial for developing multicomponent behavioral interventions
  publication-title: Clinical Trials
– volume: 42
  start-page: 42
  year: 2006
  end-page: 51
  article-title: A 2‐arm, randomized, controlled trial of a motivational interviewing‐based intervention to improve adherence to antiretroviral therapy (ART) among patients failing or initiating ART
  publication-title: Journal of Acquired Immune Deficiency Syndrome
– volume: 144
  start-page: 389
  year: 1996
  end-page: 399
  article-title: Does multiple risk factor reduction explain the reduction in fall rate in the Yale FICSIT trial?
  publication-title: American Journal of Epidemiology
– volume: 15
  start-page: 1356
  year: 2007
  end-page: 1372
  article-title: Interventions to prevent or treat obesity in preschool children: a review of evaluated programs
  publication-title: Obesity
– year: 1995
– volume: 48
  start-page: 817
  year: 1980
  end-page: 838
  article-title: A heteroskedasticity‐consistent covariance matrix estimator and a direct test for heteroskedasticity
  publication-title: Econometrica
– volume: 29
  start-page: 91
  year: 2007
  end-page: 116
  article-title: Systematic review of multifaceted interventions to improve depression care
  publication-title: General Hospital Psychiatry
– year: 1978
– volume: 66
  start-page: 688
  year: 1974
  end-page: 701
  article-title: Estimating causal effects of treatments in randomized and nonrandomized studies
  publication-title: Journal of Educational Psychology
– volume: 8
  start-page: 161
  year: 1989
  end-page: 171
  article-title: Factorial designs in clinical trials: the effects of non‐compliance and subadditivity
  publication-title: Statistics in Medicine
– volume: 3
  issue: 26
  year: 2003
  article-title: Design, analysis and presentation of factorial randomized controlled trials
  publication-title: BMC Medical Research Methodology
– volume: 79
  start-page: 516
  year: 1984
  end-page: 524
  article-title: Reducing bias in observational studies using subclassification on the propensity score
  publication-title: Journal of the American Statistical Association
– volume: 13
  start-page: 385
  year: 2003
  end-page: 401
  article-title: Optimal designs for mixed‐effects models with two random nested factors
  publication-title: Statistica Sinica
– ident: e_1_2_1_10_2
  doi: 10.1136/bmj.321.7262.694
– ident: e_1_2_1_32_2
  doi: 10.1093/oxfordjournals.aje.a008940
– ident: e_1_2_1_17_2
– ident: e_1_2_1_2_2
  doi: 10.1097/01.qai.0000219771.97303.0a
– ident: e_1_2_1_7_2
  doi: 10.1191/1740774505cn067oa
– ident: e_1_2_1_33_2
  doi: 10.1007/BF00941505
– ident: e_1_2_1_37_2
  doi: 10.1177/1740774508100973
– ident: e_1_2_1_53_2
  doi: 10.1016/j.jsp.2006.01.005
– volume-title: Empirical Model‐building and Response Surfaces
  year: 1987
  ident: e_1_2_1_48_2
  contributor:
    fullname: Box G
– volume-title: Statistical Power for the Behavioral Sciences
  year: 1988
  ident: e_1_2_1_42_2
  contributor:
    fullname: Cohen J
– ident: e_1_2_1_45_2
  doi: 10.1111/j.1360-0443.2005.01093.x
– ident: e_1_2_1_6_2
  doi: 10.1016/j.jadohealth.2005.09.013
– ident: e_1_2_1_9_2
  doi: 10.1016/j.amepre.2007.12.024
– ident: e_1_2_1_22_2
  doi: 10.1002/sim.4780080204
– volume: 29
  start-page: 4
  year: 2006
  ident: e_1_2_1_3_2
  article-title: The patient with cardiovascular disease: treatment strategies for preventing major events
  publication-title: Clinical Cardiology
  doi: 10.1002/clc.4960291403
  contributor:
    fullname: Cuffe M
– volume-title: Response Surface Methodology
  year: 1995
  ident: e_1_2_1_49_2
  contributor:
    fullname: Myers R
– ident: e_1_2_1_34_2
  doi: 10.1080/01621459.1986.10478354
– ident: e_1_2_1_28_2
  doi: 10.2307/1912934
– ident: e_1_2_1_15_2
  doi: 10.2105/AJPH.2007.127563
– ident: e_1_2_1_16_2
  doi: 10.1207/s15324796abm3001_8
– ident: e_1_2_1_41_2
  doi: 10.1200/JCO.2002.03.003
– ident: e_1_2_1_54_2
  doi: 10.1177/0002716205274941
– ident: e_1_2_1_36_2
  doi: 10.1037/h0037350
– ident: e_1_2_1_38_2
  doi: 10.15288/jsas.2005.s15.34
– start-page: 23
  volume-title: Handbook of Psychotherapy and Behavior Change
  year: 1986
  ident: e_1_2_1_30_2
  contributor:
    fullname: Kazdin A
– volume: 13
  start-page: 166
  year: 1981
  ident: e_1_2_1_50_2
  article-title: The use and analysis of staggered nested factorial designs
  publication-title: Journal of Quality Technology
  doi: 10.1080/00224065.1981.11978747
  contributor:
    fullname: Smith J
– ident: e_1_2_1_27_2
  doi: 10.1002/sim.4780121708
– ident: e_1_2_1_20_2
  doi: 10.2307/3151144
– volume: 3
  issue: 26
  year: 2003
  ident: e_1_2_1_29_2
  article-title: Design, analysis and presentation of factorial randomized controlled trials
  publication-title: BMC Medical Research Methodology
  contributor:
    fullname: Montgomery A
– ident: e_1_2_1_39_2
  doi: 10.1080/00401706.1996.10484538
– ident: e_1_2_1_35_2
  doi: 10.1080/01621459.1984.10478078
– volume-title: Variance Components
  year: 2002
  ident: e_1_2_1_52_2
  contributor:
    fullname: Searle S
– volume-title: The Design of Experiments
  year: 1942
  ident: e_1_2_1_18_2
  contributor:
    fullname: Fisher R
– ident: e_1_2_1_24_2
  doi: 10.1037/10222-006
– ident: e_1_2_1_25_2
  doi: 10.1037/a0015826
– ident: e_1_2_1_31_2
  doi: 10.1056/NEJM199409293311301
– volume: 13
  start-page: 385
  year: 2003
  ident: e_1_2_1_51_2
  article-title: Optimal designs for mixed‐effects models with two random nested factors
  publication-title: Statistica Sinica
  contributor:
    fullname: Ankerman B
– volume-title: Experiments: Planning, Analysis, and Parameter Design Optimization
  year: 2000
  ident: e_1_2_1_19_2
  contributor:
    fullname: Wu C
– ident: e_1_2_1_4_2
  doi: 10.1016/j.genhosppsych.2006.12.003
– ident: e_1_2_1_40_2
  doi: 10.1002/0471740136
– ident: e_1_2_1_12_2
  doi: 10.1136/bmj.316.7131.611
– ident: e_1_2_1_47_2
  doi: 10.15288/jsas.2005.s15.24
– ident: e_1_2_1_43_2
  doi: 10.1037/0022-006X.66.3.549
– ident: e_1_2_1_11_2
  doi: 10.1080/09540269874907
– ident: e_1_2_1_5_2
  doi: 10.1186/1472-6963-7-136
– ident: e_1_2_1_26_2
  doi: 10.2307/1266725
– ident: e_1_2_1_46_2
  doi: 10.1136/tc.2003.006189
– ident: e_1_2_1_23_2
  doi: 10.1002/sim.4780090112
– volume-title: Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building
  year: 1978
  ident: e_1_2_1_14_2
  contributor:
    fullname: Box G
– volume: 69
  start-page: 1055
  year: 1985
  ident: e_1_2_1_21_2
  article-title: Factorial designs for randomized clinical trials
  publication-title: Cancer Treatment Reports
  contributor:
    fullname: Byar D
– ident: e_1_2_1_13_2
  doi: 10.1007/BF00942173
– ident: e_1_2_1_8_2
  doi: 10.1038/oby.2007.163
– ident: e_1_2_1_44_2
  doi: 10.1016/S0738-3991(98)00128-1
SSID ssj0011527
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Snippet Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common in health...
Abstract Multicomponent interventions composed of behavioral, delivery, or implementation factors in addition to medications are becoming increasingly common...
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wiley
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StartPage 2687
SubjectTerms experimental design
Factor Analysis, Statistical
Factorial experiments
Follow-Up Studies
fractional factorial design
Health sciences
Humans
Intervention
Mass Screening
Models, Statistical
multicomponent intervention
Research Design
screening
Simulation
Smoking cessation
Smoking Cessation - methods
Smoking Cessation - statistics & numerical data
Title Developing multicomponent interventions using fractional factorial designs
URI https://api.istex.fr/ark:/67375/WNG-PG4MWW14-H/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fsim.3643
https://www.ncbi.nlm.nih.gov/pubmed/19575485
https://www.proquest.com/docview/223135105/abstract/
https://search.proquest.com/docview/733340622
https://pubmed.ncbi.nlm.nih.gov/PMC2746448
Volume 28
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