Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading

• Published in: Muscle & nerve Vol. 64; no. 5; pp. 620 - 628
• Main Authors: Kawashima, Takafumi, Ji, Rui‐Cheng, Itoh, Yuta, Agata, Nobuhide, Sasai, Nobuaki, Murakami, Taro, Sokabe, Masahiro, Hamada, Fumihiko, Kawakami, Keisuke
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2021; Wiley Subscription Services, Inc
• Subjects: Animals; Atrophy; Blood; Blood vessels; Capillaries; Energy metabolism; Growth factors; Hindlimb; Hindlimb Suspension; lymphangiogenic factor; Lymphatic system; lymphatic vessel; Lymphatic Vessels; Male; Metabolic wastes; Mice; Mice, Inbred C57BL; Muscle, Skeletal - pathology; Muscles; Muscular Atrophy - pathology; Polymerase chain reaction; Skeletal muscle; Soleus muscle; tail suspension; Tissues; Transcription; Unloading; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Western blotting; atrophy; lymphatic vessel; tail suspension; skeletal muscle; lymphangiogenic factor

Introduction/Aims Lymphatic vessels are responsible for the removal of metabolic waste from body tissues. They also play a crucial role in skeletal muscle functioning thorough their high‐energy metabolism. In this study we investigated whether disuse muscle atrophy induced by hindlimb unloading is a...