APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia

• Published in: Annals of clinical and translational neurology Vol. 12; no. 2; pp. 366 - 382
• Main Authors: Philippi, Sarah M., BP, Kailash, Raj, Towfique, Castellano, Joseph M.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2025; John Wiley and Sons Inc; Wiley
• Subjects: Age; Aged; Aged, 80 and over; Aging; Aging - genetics; Alzheimer Disease - genetics; Alzheimer's disease; Apolipoprotein E4 - genetics; Apolipoproteins E - genetics; Brain - metabolism; Brain research; Cluster analysis; Dementia; Female; Genotype; Genotype & phenotype; Health risk assessment; Humans; Male; Ontology; Plasma; Proteins; Proteome - metabolism; Risk factors; Sample variance; Visualization

Objective Recent work has bolstered the possibility that peripheral changes may be relevant to Alzheimer's disease pathogenesis in the brain. While age‐associated blood‐borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional system...