IL-13 Is Pivotal in the Fibro-Obliterative Process of Bronchiolitis Obliterans Syndrome

• Published in: Journal of Immunology Vol. 178; no. 1; pp. 511 - 519
• Main Authors: Keane, Michael P, Gomperts, Brigitte N, Weigt, Samuel, Xue, Ying Ying, Burdick, Marie D, Nakamura, Hiromi, Zisman, David A, Ardehali, Abbas, Saggar, Rajan, Lynch, Joseph P., III, Hogaboam, Cory, Kunkel, Steven L, Lukacs, Nicholas W, Ross, David J, Grusby, Michael J, Strieter, Robert M, Belperio, John A
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.01.2007
• Subjects: Animals; Antibodies - pharmacology; Bronchiolitis Obliterans - immunology; Bronchiolitis Obliterans - pathology; Bronchoalveolar Lavage Fluid - chemistry; Bronchoalveolar Lavage Fluid - immunology; Cyclosporine - pharmacology; Female; Fibrosis; Graft Rejection - immunology; Humans; Interleukin-13 - analysis; Interleukin-13 - antagonists & inhibitors; Interleukin-13 - metabolism; Interleukin-4 - metabolism; Lung Transplantation - immunology; Male; Mice; Mice, Mutant Strains; Receptors, Interleukin-13 - antagonists & inhibitors; Receptors, Interleukin-13 - genetics; Receptors, Interleukin-13 - metabolism; Syndrome; Transforming Growth Factor beta - metabolism; Up-Regulation

Acute allograft rejection is considered to be a predominately type 1 immune mediated response to the donor alloantigen. However, the type 2 immune mediated response has been implicated in multiple fibroproliferative diseases. Based on the fibro-obliterative lesion found during bronchiolitis oblitera...