Epitranscriptomics in liver disease: Basic concepts and therapeutic potential

• Published in: Journal of hepatology Vol. 73; no. 3; pp. 664 - 679
• Main Authors: Zhao, Zhicong, Meng, Jiaxiang, Su, Rui, Zhang, Jun, Chen, Jianjun, Ma, Xiong, Xia, Qiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2020
• Subjects: Epitranscriptomics; Lipid metabolism; Liver cancer; Liver disease; m6A inhibitor; m6A modification; Metastasis; mRNA metabolism; NAFLD; NASH; Liver cancer; m6A modification; NAFLD; m6A inhibitor; Epitranscriptomics; mRNA metabolism; Liver disease; Lipid metabolism; Metastasis; NASH; mA modification; mA inhibitor

The development of next-generation sequencing technology and the discovery of specific antibodies targeting chemically modified nucleotides have paved the way for a new era of epitranscriptomics. Cellular RNA is known to dynamically and reversibly undergo different chemical modifications after trans...