High-dose remifentanil increases blood pressure and heart rate mediated by sympatho-activation in conscious rats

• Published in: Journal of anesthesia Vol. 27; no. 3; pp. 325 - 332
• Main Authors: Shirasaka, Tetsuro, Yano, Takeshi, Kunitake, Takato, Tsuneyoshi, Isao
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.06.2013; Springer
• Subjects: Anesthesiology; Animals; Baroreflex - drug effects; Blood Pressure - drug effects; Complications and side effects; Consciousness - drug effects; Critical Care Medicine; Dosage and administration; Emergency Medicine; Heart beat; Heart Rate - drug effects; Hemodynamics - drug effects; Hypertension; Intensive; Male; Medicine; Medicine & Public Health; Naloxone - pharmacology; Original Article; Pain Medicine; Piperidines - pharmacology; Rats; Rats, Wistar; Receptors, Opioid, mu - agonists; Remifentanil; Risk factors; Sympathetic Nervous System - drug effects; Japan; Sinoaortic-denervated rats; Opioid; Remifentanil; Sympathetic nerve activity

Purpose The ultra-short-acting μ-opioid receptor agonist, remifentanil, is commonly used in clinical anesthesia; however, there are limited data about the hemodynamic effects of remifentanil itself without anesthetics. We investigated the effects of an ultra-short-acting μ-opioid receptor agonist, r...