Single-cell multi-omics sequencing of human early embryos

• Published in: Nature cell biology Vol. 20; no. 7; pp. 847 - 858
• Main Authors: Li, Lin, Guo, Fan, Gao, Yun, Ren, Yixin, Yuan, Peng, Yan, Liying, Li, Rong, Lian, Ying, Li, Jingyun, Hu, Boqiang, Gao, Junpeng, Wen, Lu, Tang, Fuchou, Qiao, Jie
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.07.2018
• Subjects: Accessibility; Chromatin; Deoxyribonucleic acid; DNA; DNA methylation; DNA sequencing; Embryos; Epigenetics; Fertilization; Genomes; Transcription

DNA methylation, chromatin states and their interrelationships represent critical epigenetic information, but these are largely unknown in human early embryos. Here, we apply single-cell chromatin overall omic-scale landscape sequencing (scCOOL-seq) to generate a genome-wide map of DNA methylation a...