The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies - Kumagai, Shogo; Togashi, Yosuke; Kamada, Takahiro; Sugiyama, Eri; Nishinakamura, Hitomi; Takeuchi, Yoshiko; Vitaly, Kochin; Itahashi, Kota; Maeda, Yuka; Matsui, Shigeyuki; Shibahara, Takuma; Yamashita, Yasuho; et al. (Nature immunology, 2020)
Keywords: 631/250/580; 631/67/580; Antigens - chemistry; Antigens - immunology; Apoptosis; Biomarkers; Biomarkers, Tumor; Biomedical and Life Sciences; Biomedicine; CD28 Antigens - metabolism; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell death; Cellular proteins; Effector cells; Enzymes; Gene expression; Gene Expression Regulation - drug effects; Genetic aspects; Health aspects; Humans; Immune checkpoint; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immunology; Immunomodulation; Immunoregulation; Immunosuppression; Immunotherapy; Infectious Diseases; Lymphocyte Activation - immunology; Lymphocytes; Lymphocytes T; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Staging; Neoplasms - drug therapy; Neoplasms - etiology; Neoplasms - metabolism; Neoplasms - mortality; PD-1 protein; PD-L1 protein; Peptides - chemistry; Peptides - immunology; Prognosis; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Programmed Cell Death 1 Receptor - genetics; Programmed Cell Death 1 Receptor - metabolism; Reactive Oxygen Species - metabolism; Receptors, Antigen, T-Cell - metabolism; Regulation; Signal Transduction; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Treatment Outcome; Tumor microenvironment; Tumor Microenvironment - immunology; Tumors; Japan