Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 34; no. 2; pp. 374 - 389
• Main Authors: Sweet, Robert A, Henteleff, Ruth A, Zhang, Wei, Sampson, Allan R, Lewis, David A
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.01.2009; Nature Publishing Group
• Subjects: Adult; Adult and adolescent clinical studies; Animals; Antipsychotic Agents - pharmacology; Antipsychotic Agents - therapeutic use; Auditory Cortex - drug effects; Auditory Cortex - pathology; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Dendritic Spines - drug effects; Dendritic Spines - pathology; Feedback; Female; Haloperidol - pharmacology; Haloperidol - therapeutic use; Humans; Macaca fascicularis; Male; Medical sciences; Medicine; Medicine & Public Health; Microfilament Proteins - metabolism; Microscopy, Confocal; Middle Aged; Multivariate Analysis; Nerve Tissue Proteins - metabolism; Neurosciences; original-article; Pharmacotherapy; Photomicrography; Presynaptic Terminals - physiology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychosis; Psychotic Disorders - physiopathology; Pyramidal Cells - physiology; Pyramidal Cells - ultrastructure; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - pathology; Sensory perception; United States > US; Pittsburgh Pennsylvania; dendrite; auditory cortex; pathology; schizophrenia; synapse; Human; Central nervous system; Schizophrenia; Density; Auditory cortex; Encephalon; Dendrite; Psychosis; Anatomic pathology; Synapse; Dendritic spine; Auditory pathway
• ISSN: 0893-133X; 1740-634X; 1740-634X
• DOI: 10.1038/npp.2008.67

We have previously identified reductions in mean pyramidal cell somal volume in deep layer 3 of BA 41 and 42 and reduced axon terminal density in deep layer 3 of BA 41. In other brain regions demonstrating similar deficits, reduced dendritic spine density has also been identified, leading us to hypo...