Multivalent Mechanism of Membrane Insertion by the FYVE Domain

• Published in: The Journal of biological chemistry Vol. 279; no. 4; pp. 3050 - 3057
• Main Authors: Kutateladze, Tatiana G., Capelluto, Daniel G.S., Ferguson, Colin G., Cheever, Matthew L., Kutateladze, Andrei G., Prestwich, Glenn D., Overduin, Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.01.2004; American Society for Biochemistry and Molecular Biology
• Subjects: Binding Sites; Cell Membrane - chemistry; Cell Membrane - metabolism; Humans; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Models, Molecular; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Vesicular Transport Proteins

Targeting of a wide variety of proteins to membranes involves specific recognition of phospholipid head groups and insertion into lipid bilayers. For example, proteins that contain FYVE domains are recruited to endosomes through interaction with phosphatidylinositol 3-phosphate (PtdIns(3)P). However...