Relationship between leg muscle capillary density and peak hyperemic blood flow with endurance capacity in peripheral artery disease

• Published in: Journal of applied physiology (1985) Vol. 111; no. 1; pp. 81 - 86
• Main Authors: Robbins, Jennifer L., Jones, W. Schuyler, Duscha, Brian D., Allen, Jason D., Kraus, William E., Regensteiner, Judith G., Hiatt, William R., Annex, Brian H.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.07.2011
• Subjects: Aged; Ankle Brachial Index; Biological and medical sciences; Biopsy; Capillaries - physiopathology; Case-Control Studies; Density; Exercise; Exercise Test; Female; Fundamental and applied biological sciences. Psychology; Humans; Hyperemia - physiopathology; Intermittent Claudication - diagnosis; Intermittent Claudication - etiology; Intermittent Claudication - physiopathology; Legs; Lower Extremity - blood supply; Male; Microcirculation; Middle Aged; Musculoskeletal system; Oxygen Consumption; Peripheral Arterial Disease - complications; Peripheral Arterial Disease - diagnosis; Peripheral Arterial Disease - physiopathology; Physical Endurance; Physiology; Plethysmography; Regional Blood Flow; Time Factors; Vascular diseases; Vein & artery diseases; Striated muscle; Density; Artery; Blood flow; Leg; Vertebrata; Mammalia; Blood vessel; Endurance; Circulatory system; Hemodynamics; skeletal muscle; claudication

The aim of this study was to determine if skeletal muscle capillary density is lower in patients with peripheral artery disease (PAD) and if capillary density relates to functional limitations. PAD patients with intermittent claudication (IC) have a decreased exercise tolerance due to exercise-induc...