N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys

• Published in: Acta pharmacologica Sinica Vol. 37; no. 5; pp. 637 - 644
• Main Authors: Shen, Yang, Miao, Nai-jun, Xu, Jin-lan, Gan, Xin-xin, Xu, Dan, Zhou, Li, Xue, Hong, Zhang, Wei, Lu, Li-min
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2016; Nature Publishing Group
• Subjects: Acetylcysteine - pharmacology; Acetylcysteine - therapeutic use; Angiotensin II - metabolism; Angiotensin II - pharmacology; Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Biomedical and Life Sciences; Biomedicine; Cell Line; Fibroblasts - drug effects; Fibroblasts - pathology; Fibrosis - drug therapy; Fibrosis - etiology; Fibrosis - pathology; Immunology; Internal Medicine; Kidney - drug effects; Kidney - pathology; Kidney Diseases - drug therapy; Kidney Diseases - etiology; Kidney Diseases - pathology; Male; Medical Microbiology; Mice, Inbred C57BL; N-乙酰半胱氨酸; Original; original-article; Oxidative Stress; Pharmacology/Toxicology; Reactive Oxygen Species - metabolism; Renin-Angiotensin System - drug effects; Ureteral Obstruction - complications; Ureteral Obstruction - drug therapy; Ureteral Obstruction - pathology; Vaccine; 介导; 小鼠; 成纤维细胞; 梗阻; 纤维化; 肾脏; 血管紧张素II; acetylcysteine; chronic kidney disease; angiotensin II; rat renal fibroblast NRK-49F cells; ROS; unilateral ureteral obstruction; renal fibrosis; oxidative stress

Aim： To investigate the effects of ROS scavenger N-acetylcysteine （NAC） on angiotensin II （Ang II）-mediated renal fibrosis in vivo and in vitro. Methods： Mice were subjected to unilateral ureteral obstruction （UUO）, and then treated with vehicle or NAC （250 mg/kg, ip） for 7 days. Histological change...