Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity

• Published in: Science translational medicine Vol. 3; no. 114; p. 114ra128
• Main Authors: OhAinle, Molly, Balmaseda, Angel, Macalalad, Alexander R, Tellez, Yolanda, Zody, Michael C, Saborío, Saira, Nuñez, Andrea, Lennon, Niall J, Birren, Bruce W, Gordon, Aubree, Henn, Matthew R, Harris, Eva
• Format: Journal Article
• Language: English
• Published: United States 21.12.2011
• Subjects: Dengue - pathology; Dengue Virus - genetics; Dengue Virus - immunology; Humans; Molecular Sequence Data; Severity of Illness Index

The rapid spread of dengue is a worldwide public health problem. In two clinical studies of dengue in Managua, Nicaragua, we observed an abrupt increase in disease severity across several epidemic seasons of dengue virus serotype 2 (DENV-2) transmission. Waning DENV-1 immunity appeared to increase t...