Lactobacillus Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women

• Published in: Nutrients Vol. 15; no. 8; p. 1862
• Main Authors: Ansari, AbuZar, Son, Dooheon, Hur, Young Min, Park, Sunwha, You, Young-Ah, Kim, Soo Min, Lee, Gain, Kang, Seungbeom, Chung, Yusook, Lim, Sanghyun, Kim, Young Ju
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.04.2023; MDPI
• Subjects: Antibiotics; Asymptomatic; bacterial vaginosis; cervicovaginal fluid; Colonization; Dysbacteriosis; Dysbiosis - therapy; Female; Genera; Gram-positive bacteria; Homeostasis; Humans; Infections; Lactobacilli; Lactobacillus; Metabolism; Microbiota; Microorganisms; Oral administration; Probiotics; Probiotics - therapeutic use; Sexually transmitted diseases; Stains & staining; STD; Vagina; vaginal dysbiosis; vaginal microbiota; Vaginosis, Bacterial - therapy; Womens health; United States > US; South Korea; cervicovaginal fluid; vaginal microbiota; bacterial vaginosis; Nugent score; vaginal dysbiosis; Lactobacillus; probiotics
• DOI: 10.3390/nu15081862
• ISSN: 2072-6643

Vaginal dysbiosis can lead to serious infections in asymptomatic women. probiotics (LBPs) are being investigated as a promising therapy for reversing vaginal microbiota dysbiosis. This study aimed to investigate whether administering LBPs could improve vaginal dysbiosis and facilitate the colonization of species in asymptomatic women. 36 asymptomatic women were classified based on the Nugent score as Low-NS (n = 26) and High-NS (n = 10) groups. A combination of CBT LA1, CBT LR5, and CBT LU4 was administered orally for 6 weeks. The study found that among women with a High-NS, 60% showed improved vaginal dysbiosis with a Low-NS after LBP intake, while four retained a High-NS. Among women with a Low-NS, 11.5 % switched to a High-NS. Genera associated with vaginal dysbiosis were positively correlated with the alpha diversity or NS, while a negative correlation was observed between and the alpha diversity and with the NS. Vaginal dysbiosis in asymptomatic women with an HNS improved after 6 weeks of LBP intake, and qRT-PCR revealed the colonization of spp. in the vagina. These results suggested that oral administration of this LBP could improve vaginal health in asymptomatic women with an HNS.