The blood compatibility challenge. Part 3: Material associated activation of blood cascades and cells

• Published in: Acta biomaterialia Vol. 94; pp. 25 - 32
• Main Authors: Gorbet, Maud, Sperling, Claudia, Maitz, Manfred F., Siedlecki, Christopher A., Werner, Carsten, Sefton, Michael V.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2019; Elsevier BV
• Subjects: Blood; Blood clots; Blood compatibility; Cascades; Cell activation; Coagulation cascade; Compatibility; Complement; Complement activation; Fibrin; Fibrinogen; Leukocyte activation; Leukocytes; Platelet activation; Platelets; Protein adsorption; Thrombogenicity; Thrombosis; Blood compatibility; Complement; Platelet activation; Leukocyte activation; Thrombogenicity; Coagulation cascade

[Display omitted] Following protein adsorption/activation which is the first step after the contact of material surfaces and whole blood (part 2), fibrinogen is converted to fibrin and platelets become activated and assembled in the form of a thrombus. This thrombus formation is the key feature that...