The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response

• Published in: Genes & development Vol. 21; no. 24; pp. 3381 - 3394
• Main Authors: Kwon, Sohee, Zhang, Yu, Matthias, Patrick
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 15.12.2007
• Subjects: Animals; Cells, Cultured; Histone Deacetylase 6; Histone Deacetylases - metabolism; Histone Deacetylases - physiology; Mice; Oxidative Stress; Protein Binding; Research Paper

An essential part of the cellular response to environmental stress is a reversible translational suppression, taking place in dynamic cytoplasmic structures called stress granules (SGs). We discovered that HDAC6, a cytoplasmic deacetylase that acts on tubulin and HSP90 and also binds ubiquitinated p...