Ovulation provides excessive coagulation and hepatocyte growth factor signals to cause postoperative intraabdominal adhesions

• Published in: iScience Vol. 27; no. 6; p. 109788
• Main Authors: Seenan, Vaishnavi, Hsu, Che-Fang, Subramani, Kanchana, Chen, Pao-Chu, Ding, Dah-Ching, Chu, Tang-Yuan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.06.2024; Elsevier
• Subjects: Cellular physiology; Female reproductive endocrinology; Surgery; Female reproductive endocrinology; Cellular physiology; Surgery

Postoperative adhesions show a higher occurrence in females aged 16–60, especially after pelvic surgeries. This study explores the role of ovulation in adhesion formation in mice. Ovarian surgery in mice with normal- or super-ovulation led to pronounced adhesions, whereas ovulation-defective Pgr-KO...