Molecular Identification and Characterization of Novel Human and Mouse Concentrative Na+-Nucleoside Cotransporter Proteins (hCNT3 and mCNT3) Broadly Selective for Purine and Pyrimidine Nucleosides (System cib)

• Published in: The Journal of biological chemistry Vol. 276; no. 4; pp. 2914 - 2927
• Main Authors: Ritzel, Mabel W.L., Ng, Amy M.L., Yao, Sylvia Y.M., Graham, Kathryn, Loewen, Shaun K., Smith, Kyla M., Ritzel, R. Gary, Mowles, Delores A., Carpenter, Pat, Chen, Xing-Zhen, Karpinski, Edward, Hyde, Ralph J., Baldwin, Stephen A., Cass, Carol E., Young, James D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.01.2001; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acid Sequence; Animals; Biological Transport; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Differentiation; Dilazep - pharmacology; Dipyridamole - pharmacology; Electric Conductivity; Evolution, Molecular; HL-60 Cells; Humans; Membrane Transport Proteins; Mice; Models, Molecular; Molecular Sequence Data; Purine Nucleosides - metabolism; Pyrimidine Nucleosides - metabolism; Recombinant Proteins - metabolism; Sequence Homology, Amino Acid; Sodium - metabolism; Substrate Specificity; Symporters; Thioinosine - analogs & derivatives; Thioinosine - pharmacology; Uridine - metabolism

The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1 and hCNT2 are selective for pyrimidine nucleosides (systemcit) and purine nucleosides (system cif), respectively. Both have homologs in other mammalian species and belong to a gene family (CNT) that also includes hfCNT, a...