Compensatory Changes in the Noradrenergic Nervous System in the Locus Ceruleus and Hippocampus of Postmortem Subjects with Alzheimer's Disease and Dementia with Lewy Bodies

• Published in: The Journal of neuroscience Vol. 26; no. 2; pp. 467 - 478
• Main Authors: Szot, Patricia, White, Sylvia S, Greenup, J. Lynne, Leverenz, James B, Peskind, Elaine R, Raskind, Murray A
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 11.01.2006; Society for Neuroscience
• Subjects: Adrenergic alpha-Antagonists - metabolism; Adult; Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Dendrites - ultrastructure; Female; Fluoxetine - analogs & derivatives; Fluoxetine - metabolism; Hippocampus - chemistry; Hippocampus - pathology; Humans; Idazoxan - analogs & derivatives; Idazoxan - metabolism; In Situ Hybridization; Lewy Body Disease - metabolism; Lewy Body Disease - pathology; Locus Coeruleus - chemistry; Locus Coeruleus - pathology; Male; Middle Aged; Nerve Tissue Proteins - analysis; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurobiology of Disease; Norepinephrine - chemistry; Norepinephrine - physiology; Norepinephrine Plasma Membrane Transport Proteins - analysis; Norepinephrine Plasma Membrane Transport Proteins - metabolism; Prazosin - metabolism; Receptors, Adrenergic, alpha-1 - analysis; Receptors, Adrenergic, alpha-1 - genetics; Receptors, Adrenergic, alpha-1 - metabolism; Receptors, Adrenergic, alpha-2 - analysis; Receptors, Adrenergic, alpha-2 - genetics; Receptors, Adrenergic, alpha-2 - metabolism; RNA, Messenger - analysis; RNA, Messenger - biosynthesis; Tetralones - metabolism; Tyrosine 3-Monooxygenase - analysis; Tyrosine 3-Monooxygenase - biosynthesis; Tyrosine 3-Monooxygenase - genetics
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.4265-05.2006

In Alzheimer's disease (AD), there is a significant loss of locus ceruleus (LC) noradrenergic neurons. However, functional and anatomical evidence indicates that the remaining noradrenergic neurons may be compensating for the loss. Because the noradrenergic system plays an important role in lea...