Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation
A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the small subunit processome. Coprecipitation analys...
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| Published in | RNA (Cambridge) Vol. 13; no. 9; pp. 1516 - 1527 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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United States
Cold Spring Harbor Laboratory Press
01.09.2007
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| Abstract | A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the small subunit processome. Coprecipitation analyses confirmed the association of Utp10 and Utp20 with U3 snoRNA and the early pre-rRNA processing intermediates. Particularly strong association was seen with aberrant processing intermediates, which may help target these RNAs for degradation. Genetic depletion of either protein inhibited the early pre-rRNA processing steps in 18S rRNA maturation but had little effect on pre-rRNA transcription or synthesis of the 25S or 5.8S rRNAs. The absence of the poly(A) polymerase Trf5, a component of the TRAMP5 complex and exosome cofactor, led to stabilization of the aberrant 23S RNA in strains depleted of Utp10 or Utp20. In the case of Utp10, 20S pre-rRNA synthesis was also modestly increased by this loss of surveillance activity. |
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| AbstractList | A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the small subunit processome. Coprecipitation analyses confirmed the association of Utp10 and Utp20 with U3 snoRNA and the early pre-rRNA processing intermediates. Particularly strong association was seen with aberrant processing intermediates, which may help target these RNAs for degradation. Genetic depletion of either protein inhibited the early pre-rRNA processing steps in 18S rRNA maturation but had little effect on pre-rRNA transcription or synthesis of the 25S or 5.8S rRNAs. The absence of the poly(A) polymerase Trf5, a component of the TRAMP5 complex and exosome cofactor, led to stabilization of the aberrant 23S RNA in strains depleted of Utp10 or Utp20. In the case of Utp10, 20S pre-rRNA synthesis was also modestly increased by this loss of surveillance activity. A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae . We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the small subunit processome. Coprecipitation analyses confirmed the association of Utp10 and Utp20 with U3 snoRNA and the early pre-rRNA processing intermediates. Particularly strong association was seen with aberrant processing intermediates, which may help target these RNAs for degradation. Genetic depletion of either protein inhibited the early pre-rRNA processing steps in 18S rRNA maturation but had little effect on pre-rRNA transcription or synthesis of the 25S or 5.8S rRNAs. The absence of the poly(A) polymerase Trf5, a component of the TRAMP5 complex and exosome cofactor, led to stabilization of the aberrant 23S RNA in strains depleted of Utp10 or Utp20. In the case of Utp10, 20S pre-rRNA synthesis was also modestly increased by this loss of surveillance activity. |
| Author | Dlakić, Mensur Tollervey, David Dez, Christophe |
| AuthorAffiliation | 2 Department of Microbiology, Montana State University, Bozeman, Montana 59717-3520, USA 1 Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland |
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| Snippet | A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of... A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae . We report the detailed characterization... |
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| SubjectTerms | Models, Molecular Repetitive Sequences, Amino Acid Ribonucleoproteins, Small Nuclear - genetics Ribonucleoproteins, Small Nuclear - physiology Ribonucleoproteins, Small Nucleolar - genetics Ribonucleoproteins, Small Nucleolar - physiology RNA Processing, Post-Transcriptional - physiology RNA, Ribosomal, 18S - biosynthesis RNA, Small Nucleolar - genetics RNA, Small Nucleolar - physiology Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - physiology Signal Transduction - genetics |
| Title | Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation |
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