Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance

• Published in: Frontiers in neuroendocrinology Vol. 24; no. 4; pp. 225 - 253
• Main Author: Sahu, Abhiram
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2003
• Subjects: 3',5'-Cyclic-AMP Phosphodiesterases - metabolism; Animals; Cyclic AMP - metabolism; Cyclic Nucleotide Phosphodiesterases, Type 3; DNA-Binding Proteins - metabolism; Energy Metabolism - physiology; Homeostasis; Humans; Hypothalamus - cytology; Hypothalamus - metabolism; Janus Kinase 2; Leptin - metabolism; Neurons - metabolism; Obesity - physiopathology; Phosphatidylinositol 3-Kinases - metabolism; Protein-Tyrosine Kinases - metabolism; Proto-Oncogene Proteins; Second Messenger Systems - physiology; Signal Transduction - physiology; STAT3 Transcription Factor; Trans-Activators - metabolism

Leptin, the long-sought satiety factor of adipocytes origin, has emerged as one of the major signals that relay the status of fat stores to the hypothalamus and plays a significant role in energy homeostasis. Understanding the mechanisms of leptin signaling in the hypothalamus during normal and path...