Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster

• Published in: iScience Vol. 28; no. 2; p. 111837
• Main Authors: Jiang, Ren-Di, Luo, Yun-Zhe, Lin, Hao-Feng, Zheng, Xiao-Shuang, Zeng, Wen-Tao, Liu, Mei-Qin, Deng, Hao-Hao, Wang, Qi, Lai, Ya-Na, Chen, Ying, Guo, Zi-Shuo, Zeng, Ya, Gong, Qian-Chun, Qiu, Chen, Dong, Mei, Wang, Xi, Wang, Zi-Yi, Ji, Li-Na, Hou, Pan-Pan, Li, Qian, Shen, Xu-Rui, Li, Bei, Gao, Yun, Zhang, Ai-Hua, Jiang, Ting-Ting, Shi, Ai-Min, Zhou, Peng, Lin, Xin-Hua, Deng, Zi-Qing, Li, Jian-Min, Shi, Zheng-Li
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.02.2025; Elsevier
• Subjects: Immune response; Omics; Virology; Immune response; Omics; Virology

Comorbidities, such as obesity, increase the risk of severe COVID-19. However, the mechanisms underlying severe illnesses in individuals with obesity are poorly understood. Here, we used gene-edited leptin knock out (Leptin−/−) obese hamsters to establish a severe infection model. This model exhibit...