The structure-based cancer-related single amino acid variation prediction

• Published in: Scientific reports Vol. 11; no. 1; p. 13599
• Main Authors: Liu, Jia-Jun, Yu, Chin-Sheng, Wu, Hsiao-Wei, Chang, Yu-Jen, Lin, Chih-Peng, Lu, Chih-Hao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 30.06.2021; Nature Publishing Group UK; Nature Portfolio
• Subjects: Amino acid substitution; Amino acids; Cancer; Cancer research; Computer applications; Correlation coefficient; Microenvironments; Precision medicine; Predictions; Protein structure; Proteins; Structure-function relationships

Abstract Single amino acid variation (SAV) is an amino acid substitution of the protein sequence that can potentially influence the entire protein structure or function, as well as its binding affinity. Protein destabilization is related to diseases, including several cancers, although using traditi...