MAMDC2, a gene highly expressed in microglia in experimental models of Alzheimers Disease, positively regulates the innate antiviral response during neurotropic virus infection

• Published in: The Journal of infection Vol. 84; no. 2; pp. 187 - 204
• Main Authors: Wang, Yiliang, Luo, Weisheng, Wang, Xiaohui, Ma, Yuying, Huang, Lianzhou, Wang, Yifei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2022
• Subjects: Alzheimer Disease - metabolism; Animals; Antiviral Agents; Encephalitis, Herpes Simplex; HSV-1; Humans; Immunity, Innate; Innate antiviral response; MAMDC2; Mice; Microglia; Microglia - metabolism; Models, Theoretical; Neurotropic virus; Neurotropic virus; Innate antiviral response; HSV-1; MAMDC2; Microglia

•MAMDC2 is upregulated significantly in microglia upon neurotropic herpesvirus infection.•MAMDC2 is upregulated remarkably in microglia isolated from a series of AD mice.•MAMDC2 enhances the polymerization of STING, facilitating the expression of type I interferon.•MAMDC2 interacts with STING via it...